Therapeutic targets of triple-negative breast cancer: a review

被引：165
作者：
Jamdade, Vinayak S. [1 ]
Sethi, Nikunj [2 ,3 ]
Mundhe, Nitin A. [1 ]
Kumar, Parveen [1 ]
Lahkar, Mangala [1 ,4 ]
Sinha, Neeraj [2 ,3 ]
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Gauhati Med Coll, Lab Mol Pharmacol & Toxicol, Gauhati 781032, Assam, India
[2] Acad Sci & Innovat Res AcSIR, New Delhi, India
[3] CSIR, Cent Drug Res Inst, Div Toxicol, Lucknow 226031, Uttar Pradesh, India
[4] Gauhati Med Coll, Dept Pharmacol, Lab Pharmacol, Gauhati, India
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2015年 / 172卷 / 17期
关键词：
GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; CONCISE GUIDE; SIGNALING PATHWAY; PROTEIN-KINASE; TGF-BETA; HEDGEHOG; CELLS; PHARMACOLOGY; DOWNSTREAM;
D O I：
10.1111/bph.13211
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Breast cancer (BC) is the second most common cause of cancer deaths. Triple-negative breast cancer (TNBC) does not show immunohistochemical expression of oestrogen receptors, progesterone receptors or HER2. At present, no suitable treatment option is available for patients with TNBC. This dearth of effective conventional therapies for the treatment of advanced stage breast cancer has provoked the development of novel strategies for the management of patients with TNBC. This review presents recent information associated with different therapeutic options for the treatment of TNBC focusing on promising targets such as the Notch signalling, Wnt/-catenin and Hedgehog pathways, in addition to EGFR, PARP1, mTOR, TGF- and angiogenesis inhibitors.
引用
收藏
页码：4228 / 4237
页数：10
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