Metal-Free Decarboxylative Cyclization/Ring Expansion: Construction of Five-, Six-, and Seven-Membered Heterocycles from 2-Alkynyl Benzaldehydes and Cyclic Amino Acids

被引：39

作者：

Samala, Srinivas ^{[1
]}

Singh, Gajendra ^{[2
,3
]}

Kumar, Ravi ^{[1
,3
]}

Ampapathi, Ravi Sankar ^{[2
,3
]}

Kundu, Bijoy ^{[1
,3
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India

[2] CSIR Cent Drug Res Inst, NMR Div, Sophisticated & Analyt Instrument Facil, Lucknow 226031, Uttar Pradesh, India

[3] Acad Sci & Innovat Res, New Delhi 110001, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 33期

关键词：

amino acids; azomethine ylides; heterocycles; ring expansion; synthetic methods; ONE-POT SYNTHESIS; AZOMETHINE YLIDES; FUNCTIONALIZATION; BOND;

D O I：

10.1002/anie.201504429

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one pot synthesis of 1H-benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1,2-b]azepines from 2-alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one CN and two CC bonds) by a metal-free decarboxylation/cyclization/one-carbon ring expansion sequence in one pot.

引用

页码：9564 / 9567

页数：4

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