Structures and anti-cancer properties of two binuclear copper complexes

被引：36

作者：

Qin, Xiu Ying ^{[1
,2
]}

Yang, Li Cong ^{[1
]}

Le, Fang Ling ^{[1
]}

Yu, Qian Qian ^{[1
]}

Sun, Dong Dong ^{[1
]}

Liu, Ya Nan ^{[3
]}

Liu, Jie ^{[1
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

[2] Guilin Med Univ, Coll Pharm, Guilin, Peoples R China

[3] Chinese Univ Hong Kong, Dept Biol, Hong Kong, Hong Kong, Peoples R China

来源：

DALTON TRANSACTIONS | 2013年 / 42卷 / 41期

基金：

中国国家自然科学基金;

关键词：

OXYGEN SPECIES ROS; APOPTOSIS; DNA; GROWTH; CELLS;

D O I：

10.1039/c3dt51548f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The crystals of two binuclear copper-based complexes were obtained. One complex can remarkably induce apoptosis and inhibit angiogenesis to mediate tumour growth at a greater extent. Furthermore, this complex showed a strong energy-dependent and non-endocytotic uptake and exhibited multiple anticancer functions by inhibiting the expressions of p-Akt and p-Erk1/2 proteins and by decreasing the levels of reactive oxygen species.

引用

页码：14681 / 14684

页数：4

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