Aberrant nuclear BCL10 expression and tack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphoma

被引:26
作者
Gallardo, Fernando
Bellosillo, Beatriz
Espinet, Blanca
Pujol, Ramon M.
Estrach, Teresa
Servitje, Octavio
Romagosa, Vicenc
Barranco, Caries
Boluda, Susana
Garcia, Mar
Sole, Francesc
Ariza, Aurelio
Serrano, Sergi
机构
[1] Hosp Mar, Dept Dermatol, IMAS, E-08003 Barcelona, Spain
[2] Catalonian Cutaneous Lymphoma Network, Barcelona, Spain
[3] Hosp Mar, Dept Pathol, IMAS, Mol Biol & Cytogen Labs, E-08003 Barcelona, Spain
[4] Hosp Clin Barcelona, Dept Dermatol, IDIBAPS, E-08036 Barcelona, Spain
[5] Bellvitge Hosp, Dept Dermatol, IDIBELL, Barcelona, Spain
[6] Bellvitge Hosp, Dept Pathol, IDIBELL, Barcelona, Spain
[7] Hosp Badalona Germans Trias & Pujol, Dept Pathol, Barcelona, Spain
关键词
BCL10; cutaneous lymphoma; MALT1; t(11; 18)(q21; q21);
D O I
10.1016/j.humpath.2006.02.012
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Inhibition of apoptosis seems to play an important role in the pathogenesis of marginal zone lymphoma. Apoptosis regulator B-cell lymphoma 10 (BCL10) may show aberrant nuclear localization in some aggressive extracutaneous MALT lymphomas. often in association with a MALT1 gene t(11;18)(q21;q21) translocation. The possible occurrence of this association in primary cutaneous marginal zone lymphoma (PCMZL) remains insufficiently explored. The aim of this study was to evaluate BCL10 protein expression pattern and its possible relationship to the presence of t(11:18)(q21;q21) and other MALT I gene abnormalities in PCMZL and to assess their clinical significance. The study included 42 consecutive PCMZL patients diagnosed on the basis of the World Health Organization/European Organization for the Research and Treatment of Cancer classification criteria. BCL10 expression was immunohistochemically evaluated in all cases, whereas t(11;18)(q21;q21) reverse transcriptase polymerase chain reaction amplification was performed on 21 samples. In addition, the presence of other MALT1 gene translocations was explored in 26 samples by interphase fluorescence in situ hybridization using a MALT1 locus-specific probe. We observed the presence of aberrant nuclear BCL10 expression in a significant number of PCMZL cases (36%, 15/42). This aberrant expression was significantly related to the development of extracutaneous disease. In contrast, neither the t(11;18)(q21;q21) translocation nor other MALT I gene translocations could be demonstrated. t(11;18)(q21;q21), strongly linked to extracutaneous MALT lymphomas, does not seem to play a role in PCMZL. The participation of other MALT1 gene translocations in PCMZL pathogenesis seems also unlikely. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:867 / 873
页数:7
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