Anticoagulant Activity and Platelet Aggregation in Blood Plasma from Rats after Intranasal Administration of Adenosine Triphosphate and Its Complex with Heparin

被引：0

作者：

Pastorova, W. E. ^{[1
]}

Lyapina, L. A. ^{[1
]}

Obergan, T. Y. ^{[1
]}

Shubina, T. A. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, BA Kudryashov Lab Protect Syst Blood, Dept Human & Anim Physiol, Moscow 117234, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 03期

关键词：

adenosine triphosphate-heparin complex; anticoagulant activity; platelet aggregation;

D O I：

10.1007/s10517-008-0282-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Fourfold intranasal administration of ATP was followed by an increase in anticoagulant activity and decrease in platelet aggregation in blood plasma of healthy rats and, particularly, of animals with suppressed function of the anticoagulant system. These changes decrease the risk of the prethrombotic state. Complex of ATP and high-molecular-weight heparin decreased platelet aggregation only in the blood from healthy animals, but increased anticoagulant potential of plasma hemostasis in prethrombotic animals.

引用

页码：273 / 275

页数：3

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