Homocysteine and C-Reactive Protein Levels Are Associated With Frailty in Older Spaniards: The Toledo Study for Healthy Aging

被引:36
作者
Alvarez-Sanchez, Nuria [1 ]
Isabel Alvarez-Rios, Ana [2 ]
Miguel Guerrero, Juan [1 ,2 ,3 ]
Jose Garcia-Garcia, Francisco [4 ]
Rodriguez-Manas, Leocadio [5 ,6 ]
Cruz-Chamorro, Ivan [1 ,3 ]
Judith Lardone, Patricia [1 ,3 ]
Carrillo-Vico, Antonio [1 ,3 ]
机构
[1] Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
[2] Virgen del Rocio Univ Hosp, Dept Clin Biochem, Seville, Spain
[3] Univ Seville, Fac Med, Dept Bioquim Med & Biol Mol & Inmunol, Seville, Spain
[4] Complejo Hosp Toledo, Hosp Virgen del Valle, Div Geriatr Med, Toledo, Spain
[5] Hosp Univ Getafe Madrid, Serv Geriatria, Madrid, Spain
[6] Hosp Univ Getafe Madrid, Fdn Invest Biomed, Madrid, Spain
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2020年 / 75卷 / 08期
关键词
Prefrailty; Fried's criteria; Inflammation; Biochemical markers; INFLAMMATORY MARKERS; CARDIOVASCULAR-DISEASE; CARE PROFESSIONALS; OXIDATIVE STRESS; SPANISH WOMEN; VITAMIN-D; ADULTS; RISK; PEOPLE; POPULATION;
D O I
10.1093/gerona/glz168
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
High-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) are inflammation markers but are also related to cardiovascular diseases, disability, or higher risk of death. Although inflammation is considered to be associated with frailty, data regarding the association between hsCRP or Hcy and frailty are controversial or scarce, especially with respect to their association with prefrailty. Thus, our objective was to study the association of hsCRP and Hcy with prefrailty and frailty in 1,211 Spanish men and women aged 65-98 years from the Toledo Study for Healthy Aging (TSHA) cohort, classified according to Fried's criteria. Hcy was independently associated with frailty (odds ratio [OR] = 1.06; 95% confidence interval [CI]: 1.01-1.12), whereas hsCRP was independently associated with both prefrailty (OR = 1.03; 95% CI: 1.01-1.06) and frailty (OR = 1.07; 95% CI: 1.02-1.12). Furthermore, both markers were positively correlated with the number of Fried's criteria that were met and were independently associated with the criteria of exhaustion (Hcy: OR = 1.03, 95% CI: 1.00-1.06), weakness (hsCRP: OR = 1.03, 95% CI: 1.01-1.05), and low physical activity (hsCRP: OR = 1.04, 95% CI: 1.02-1.06). Thus, our results highlight the importance of inflammation in age-related physical decline and, in particular, its association with fatigue, low strength, and decreased physical activity.
引用
收藏
页码:1488 / 1494
页数:7
相关论文
共 57 条
[1]   Three-year change in inflammatory markers in elderly people and mortality: The Invecchiare in Chianti study [J].
Alley, Dawn E. ;
Crimmins, Eileen ;
Bandeen-Roche, Karen ;
Guralnik, Jack ;
Ferrucci, Luigi .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2007, 55 (11) :1801-1807
[2]   CRP 1846G>A polymorphism increases risk of frailty [J].
Almeida, Osvaldo P. ;
Norman, Paul E. ;
van Bocicxmeer, Frank M. ;
Hankey, Graemei. ;
Flicker, Leon .
MATURITAS, 2012, 71 (03) :261-266
[3]   Associations between frailty and serum N-terminal propeptide of type I procollagen and 25-hydroxyvitamin D in older Spanish women: The Toledo Study for Healthy Aging [J].
Alvarez-Rios, Ana I. ;
Guerrero, Juan M. ;
Garcia-Garcia, Francisco J. ;
Rodriguez-Manas, Leocadio ;
Medrano-Campillo, Pablo ;
de la Torre Lanza, Maria A. ;
Alvarez-Sanchez, Nuria ;
Carrillo-Vico, Antonio .
EXPERIMENTAL GERONTOLOGY, 2015, 69 :79-84
[4]   Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging [J].
Alvarez-Sanchez, Nuria ;
Isabel Alvarez-Rios, Ana ;
Miguel Guerrero, Juan ;
Jose Garcia-Garcia, Francisco ;
Rodriguez-Manas, Leocadio ;
Cruz-Chamorro, Ivan ;
Judith Lardone, Patricia ;
Carrillo-Vico, Antonio .
EXPERIMENTAL GERONTOLOGY, 2018, 108 :201-208
[5]   Measuring Systemic Inflammatory Regulation in Older Adults: Evidence and Utility [J].
Bandeen-Roche, Karen ;
Walston, Jeremy D. ;
Huang, Yi ;
Semba, Richard D. ;
Ferrucci, Luigi .
REJUVENATION RESEARCH, 2009, 12 (06) :403-410
[6]   Insulin resistance and inflammation as precursors of frailty - The cardiovascular health study [J].
Barzilay, Joshua I. ;
Blaum, Caroline ;
Moore, Tisha ;
Xue, Qian Li ;
Hirsch, Calvin H. ;
Walston, Jeremy D. ;
Fried, Linda P. .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (07) :635-641
[7]   C-reactive protein is a mediator of cardiovascular disease [J].
Bisoendial, Radjesh J. ;
Boekholdt, S. Matthijs ;
Vergeer, Menno ;
Stroes, Erik S. G. ;
Kastelein, John J. P. .
EUROPEAN HEART JOURNAL, 2010, 31 (17) :2087-U1505
[8]   The association between vitamin D and inflammation with the 6-minute walk and frailty in patients with heart failure [J].
Boxer, Rebecca S. ;
Dauser, Deborah A. ;
Walsh, Stephen J. ;
Hager, W. David ;
Kenny, Anne M. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2008, 56 (03) :454-461
[9]   Frailty: An Emerging Public Health Priority [J].
Cesari, Matteo ;
Prince, Martin ;
Thiyagarajan, Jotheeswaran Amuthavalli ;
De Carvalho, Islene Araujo ;
Bernabei, Roberto ;
Chan, Piu ;
Miguel Gutierrez-Robledo, Luis ;
Michel, Jean-Pierre ;
Morley, John E. ;
Ong, Paul ;
Manas, Leocadio Rodriguez ;
Sinclair, Alan ;
Won, Chang Won ;
Beard, John ;
Vellas, Bruno .
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2016, 17 (03) :188-192
[10]   Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population [J].
Chang, Chun-Chin ;
Hsu, Chien-Yi ;
Huang, Po-Hsun ;
Liu, Li-Kuo ;
Chen, Liang-Kung ;
Chen, Jaw-Wen ;
Lin, Shing-Jong .
GERIATRICS & GERONTOLOGY INTERNATIONAL, 2017, 17 (12) :2449-2454