共 57 条
Homocysteine and C-Reactive Protein Levels Are Associated With Frailty in Older Spaniards: The Toledo Study for Healthy Aging
被引:36
作者:

Alvarez-Sanchez, Nuria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Isabel Alvarez-Rios, Ana
论文数: 0 引用数: 0
h-index: 0
机构:
Virgen del Rocio Univ Hosp, Dept Clin Biochem, Seville, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Miguel Guerrero, Juan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
Virgen del Rocio Univ Hosp, Dept Clin Biochem, Seville, Spain
Univ Seville, Fac Med, Dept Bioquim Med & Biol Mol & Inmunol, Seville, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Jose Garcia-Garcia, Francisco
论文数: 0 引用数: 0
h-index: 0
机构:
Complejo Hosp Toledo, Hosp Virgen del Valle, Div Geriatr Med, Toledo, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Rodriguez-Manas, Leocadio
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Univ Getafe Madrid, Serv Geriatria, Madrid, Spain
Hosp Univ Getafe Madrid, Fdn Invest Biomed, Madrid, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Cruz-Chamorro, Ivan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
Univ Seville, Fac Med, Dept Bioquim Med & Biol Mol & Inmunol, Seville, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Judith Lardone, Patricia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
Univ Seville, Fac Med, Dept Bioquim Med & Biol Mol & Inmunol, Seville, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain

Carrillo-Vico, Antonio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
Univ Seville, Fac Med, Dept Bioquim Med & Biol Mol & Inmunol, Seville, Spain Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
机构:
[1] Univ Seville, Inst Biomed Sevilla, CSIC, Junta Andalucia,IBiS,HUVR, Seville, Spain
[2] Virgen del Rocio Univ Hosp, Dept Clin Biochem, Seville, Spain
[3] Univ Seville, Fac Med, Dept Bioquim Med & Biol Mol & Inmunol, Seville, Spain
[4] Complejo Hosp Toledo, Hosp Virgen del Valle, Div Geriatr Med, Toledo, Spain
[5] Hosp Univ Getafe Madrid, Serv Geriatria, Madrid, Spain
[6] Hosp Univ Getafe Madrid, Fdn Invest Biomed, Madrid, Spain
来源:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
|
2020年
/
75卷
/
08期
关键词:
Prefrailty;
Fried's criteria;
Inflammation;
Biochemical markers;
INFLAMMATORY MARKERS;
CARDIOVASCULAR-DISEASE;
CARE PROFESSIONALS;
OXIDATIVE STRESS;
SPANISH WOMEN;
VITAMIN-D;
ADULTS;
RISK;
PEOPLE;
POPULATION;
D O I:
10.1093/gerona/glz168
中图分类号:
R592 [老年病学];
C [社会科学总论];
学科分类号:
03 ;
0303 ;
100203 ;
摘要:
High-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) are inflammation markers but are also related to cardiovascular diseases, disability, or higher risk of death. Although inflammation is considered to be associated with frailty, data regarding the association between hsCRP or Hcy and frailty are controversial or scarce, especially with respect to their association with prefrailty. Thus, our objective was to study the association of hsCRP and Hcy with prefrailty and frailty in 1,211 Spanish men and women aged 65-98 years from the Toledo Study for Healthy Aging (TSHA) cohort, classified according to Fried's criteria. Hcy was independently associated with frailty (odds ratio [OR] = 1.06; 95% confidence interval [CI]: 1.01-1.12), whereas hsCRP was independently associated with both prefrailty (OR = 1.03; 95% CI: 1.01-1.06) and frailty (OR = 1.07; 95% CI: 1.02-1.12). Furthermore, both markers were positively correlated with the number of Fried's criteria that were met and were independently associated with the criteria of exhaustion (Hcy: OR = 1.03, 95% CI: 1.00-1.06), weakness (hsCRP: OR = 1.03, 95% CI: 1.01-1.05), and low physical activity (hsCRP: OR = 1.04, 95% CI: 1.02-1.06). Thus, our results highlight the importance of inflammation in age-related physical decline and, in particular, its association with fatigue, low strength, and decreased physical activity.
引用
收藏
页码:1488 / 1494
页数:7
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h-index: 0
机构:
Univ Hosp Toulouse, Gerontopole, Toulouse, France
Univ Toulouse 3, INSERM UMR1027, F-31062 Toulouse, France Univ Hosp Toulouse, Gerontopole, Toulouse, France
[10]
Association between frailty and carotid intima media thickness and inflammatory marker in an elderly population
[J].
Chang, Chun-Chin
;
Hsu, Chien-Yi
;
Huang, Po-Hsun
;
Liu, Li-Kuo
;
Chen, Liang-Kung
;
Chen, Jaw-Wen
;
Lin, Shing-Jong
.
GERIATRICS & GERONTOLOGY INTERNATIONAL,
2017, 17 (12)
:2449-2454

Chang, Chun-Chin
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机构:
Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taoyuan Branch, Taoyuan, Taiwan
Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei, Taiwan
Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taoyuan Branch, Taoyuan, Taiwan

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Huang, Po-Hsun
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h-index: 0
机构:
Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan
Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei, Taiwan
Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taoyuan Branch, Taoyuan, Taiwan

Liu, Li-Kuo
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Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, Taipei, Taiwan
Natl Yang Ming Univ, Aging & Hlth Res Ctr, Taipei, Taiwan Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taoyuan Branch, Taoyuan, Taiwan

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Lin, Shing-Jong
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h-index: 0
机构:
Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan
Taipei Vet Gen Hosp, Dept Med Res, Taipei, Taiwan
Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei, Taiwan
Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan
Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med, Taipei, Taiwan Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taoyuan Branch, Taoyuan, Taiwan