Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

被引：61
|
作者：
Maurya, Ram Awatar [1 ]
Min, Kyoung-Ik [2 ]
Kim, Dong-Pyo [2 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Div Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India
[2] Pohang Univ Sci & Technol POSTECH, Dept Chem Engn, Natl Creat Res Ctr Appl Microfluid Chem CAMC, Pohang, South Korea
来源：
GREEN CHEMISTRY | 2014年 / 16卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
BETA-KETO-ESTERS; HIGHLY ENANTIOSELECTIVE SYNTHESIS; SELECTIVE SYNTHESIS; DIAZO-COMPOUNDS; RAPID ACCESS; MICROREACTOR; SAFE; EFFICIENT; ALDEHYDES; DIAZOESTERS;
D O I：
10.1039/c3gc41226a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An integrated microfluidic system for multiple reactions and separations of hazardous ethyl diazoacetate is presented. The integrated techniques include: a droplet technique for liquid-liquid and/or gas-liquid separation and in situ generation of the toxic reagent, a dual channel membrane technique based on a cheap polymeric microseparator for liquid-liquid separation, and a capillary microreactor for carrying out cascade reactions in a sequential and continuous manner.
引用
收藏
页码：116 / 120
页数：5
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