Akaeolide, a Carbocyclic Polyketide from Marine-Derived Streptomyces

被引:15
作者
Igarashi, Yasuhiro [1 ,2 ]
Zhou, Tao [1 ,2 ]
Sato, Seizo [3 ]
Matsumoto, Takashi [4 ]
Yu, Linkai [1 ,2 ]
Oku, Naoya [1 ,2 ]
机构
[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Imizu, Toyama 9390398, Japan
[2] Toyama Prefectural Univ, Dept Biotechnol, Imizu, Toyama 9390398, Japan
[3] Nippon Suisun Kaisha Ltd, Tokyo Innovat Ctr, Cent Res Lab, Hachioji, Tokyo 1920991, Japan
[4] Rigaku Corp, Applicat Labs, Akishima, Tokyo 1968666, Japan
关键词
ANTITUMOR ANTIBIOTICS; POLYCYCLIC POLYKETIDE; COCHLEAMYCINS; LANKACIDIN;
D O I
10.1021/ol402661r
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Akaeolide, a novel polycyclic polyketide, was isolated from the culture extract of a marine-derived actinomycete belonging to the genus Streptomyces. The planar structure of the new compound was elucidated by spectroscopic analysis including NMR and MS, and the absolute configuration was determined by X-ray crystallographic analysis of its chlorinated derivative. Akaeolide possesses a 15-membered carbocyclic framework, apparently derived from the malonate pathway, with a tetrahydrofuran ring and a beta-keto-delta-lactone unit.
引用
收藏
页码:5678 / 5681
页数:4
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