Akaeolide, a Carbocyclic Polyketide from Marine-Derived Streptomyces

被引：15

作者：

Igarashi, Yasuhiro ^{[1
,2
]}

Zhou, Tao ^{[1
,2
]}

Sato, Seizo ^{[3
]}

Matsumoto, Takashi ^{[4
]}

Yu, Linkai ^{[1
,2
]}

Oku, Naoya ^{[1
,2
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Imizu, Toyama 9390398, Japan

[2] Toyama Prefectural Univ, Dept Biotechnol, Imizu, Toyama 9390398, Japan

[3] Nippon Suisun Kaisha Ltd, Tokyo Innovat Ctr, Cent Res Lab, Hachioji, Tokyo 1920991, Japan

[4] Rigaku Corp, Applicat Labs, Akishima, Tokyo 1968666, Japan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 22期

关键词：

ANTITUMOR ANTIBIOTICS; POLYCYCLIC POLYKETIDE; COCHLEAMYCINS; LANKACIDIN;

D O I：

10.1021/ol402661r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Akaeolide, a novel polycyclic polyketide, was isolated from the culture extract of a marine-derived actinomycete belonging to the genus Streptomyces. The planar structure of the new compound was elucidated by spectroscopic analysis including NMR and MS, and the absolute configuration was determined by X-ray crystallographic analysis of its chlorinated derivative. Akaeolide possesses a 15-membered carbocyclic framework, apparently derived from the malonate pathway, with a tetrahydrofuran ring and a beta-keto-delta-lactone unit.

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收藏

页码：5678 / 5681

页数：4

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