Synthesis of fibrinolytic active silver nanoparticle using wheat bran xylan as a reducing and stabilizing agent

被引：72

作者：

Harish, B. S. ^{[1
]}

Uppuluri, Kiran Babu ^{[1
]}

Anbazhagan, Veerappan ^{[1
]}

机构：

[1] SASTRA Univ, Sch Chem & Biotechnol, Thanjavur 613401, Tamil Nadu, India

来源：

CARBOHYDRATE POLYMERS | 2015年 / 132卷

关键词：

Xylan; Wheat bran; Silver nanoparticles; Fibrinolytic; PROMISING ANTIBACTERIAL AGENT; SELECTIVE COLORIMETRIC SENSOR; GREEN SYNTHESIS; COPPER NANOPARTICLES; FACILE; COAGULATION; COATINGS; THERAPY; MERCURY;

D O I：

10.1016/j.carbpol.2015.06.069

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A facile synthesis of highly stable silver nanoparticles (AgNPs) was reported using a biopolymer, xylan as both a reducing and stabilizing agent. Xylan was isolated from waste biomass, wheat bran (WB) by alkaline treatment and was characterized by Fehling's test, dinitrosalicylic acid assay, FTIR, H-1 NMR and C-13 NMR. The synthesized nanoparticles were characterized by UV-Vis spectroscopy and transmission electron microscopy. The nanoparticles were polydispersed with the size ranging from 20 to 45 nm. The synthesized WB-xylan AgNPs showed excellent free radical scavenging activity. In addition, WB-xylan AgNPs showed fibrinolytic activity as evidenced by the zone of clearance in fibrin plate assay. The biomedical potential of the WB-xylan AgNPs was demonstrated by dissolution of preformed blood clots. These results suggest that the development of xylan-metal nanoparticle composite would be feasible to treat thrombus related diseases. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：104 / 110

页数：7

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