CD4+, CD56+ Mycosis Fungoides: Case Report and Review of the Literature

被引:10
作者
Horst, Basil A. [3 ]
Kasper, Richard
LeBoit, Philip E. [1 ,2 ]
机构
[1] Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94115 USA
[2] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA
[3] Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY USA
关键词
CD56(+) mycosis fungoides; T-CELL LYMPHOMA; CUTANEOUS LYMPHOMAS; DISEASE;
D O I
10.1097/DAD.0b013e31818ffbe8
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
This case report details an 85-year-old woman who presented with mycosis fungoides (MF), clinical stage IA. Bilateral lesions on the upper thighs were responsive to topical steroid therapy. Biopsies showed band-like dermal infiltrates of medium-sized lymphocytes with marked epidermotropism, including large intraepidermal lymphocytes with nuclear convolutions, consistent with MF Immunohistochemical staining revealed that the lesional cells were CD56(+), but unlike the case in previous reports of CD56(+) MF, they also expressed CD4 and T-cell intracellular antigen 1 and did not express CD8. To our knowledge, this is the first description of a case of MF with a CD4(+), CD8(-), CD56(+), T-cell intracellular antigen I-positive immunophenotype. At 85 years of age, the patient is older than all previously described patients with CD56(+) MF Despite an immunophenotype observed more commonly in aggressive forms of cutaneous T-cell lymphoma, the clinical presentation is that of typical ME The patient presented with limited disease and after 12 months of follow-tip has not progressed beyond stage 1A.
引用
收藏
页码:74 / 76
页数:3
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