共 11 条
CD4+, CD56+ Mycosis Fungoides: Case Report and Review of the Literature
被引:10
作者:

Horst, Basil A.
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机构:
Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY USA Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94115 USA

Kasper, Richard
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机构: Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94115 USA

LeBoit, Philip E.
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机构:
Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94115 USA
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94115 USA
机构:
[1] Univ Calif San Francisco, Dept Pathol, Serv Dermatopathol, San Francisco, CA 94115 USA
[2] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA
[3] Columbia Univ, Med Ctr, Dept Pathol & Cell Biol, New York, NY USA
关键词:
CD56(+) mycosis fungoides;
T-CELL LYMPHOMA;
CUTANEOUS LYMPHOMAS;
DISEASE;
D O I:
10.1097/DAD.0b013e31818ffbe8
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
This case report details an 85-year-old woman who presented with mycosis fungoides (MF), clinical stage IA. Bilateral lesions on the upper thighs were responsive to topical steroid therapy. Biopsies showed band-like dermal infiltrates of medium-sized lymphocytes with marked epidermotropism, including large intraepidermal lymphocytes with nuclear convolutions, consistent with MF Immunohistochemical staining revealed that the lesional cells were CD56(+), but unlike the case in previous reports of CD56(+) MF, they also expressed CD4 and T-cell intracellular antigen 1 and did not express CD8. To our knowledge, this is the first description of a case of MF with a CD4(+), CD8(-), CD56(+), T-cell intracellular antigen I-positive immunophenotype. At 85 years of age, the patient is older than all previously described patients with CD56(+) MF Despite an immunophenotype observed more commonly in aggressive forms of cutaneous T-cell lymphoma, the clinical presentation is that of typical ME The patient presented with limited disease and after 12 months of follow-tip has not progressed beyond stage 1A.
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页码:74 / 76
页数:3
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