Understanding immunosenescence to improve responses to vaccines

被引：572

作者：

Goronzy, Joerg J. ^{[1
,2
]}

Weyand, Cornelia M. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Sch Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

[2] Palo Alto Vet Adm Hlth Care Syst, Dept Med, Palo Alto, CA USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 05期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSES; HEMATOPOIETIC STEM-CELLS; AGE-RELATED-CHANGES; INFLUENZA VACCINE; IMMUNE SENESCENCE; SIGNALING PATHWAYS; GERMINAL-CENTERS; ELDERLY-PEOPLE; OLD-AGE; DIFFERENTIATION;

D O I：

10.1038/ni.2588

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate protective immunity. The age-dependent decrease in immunological competence, often referred to as 'immunosenescence', results from the progressive deterioration of innate and adaptive immune responses. Most insights into mechanisms of immunological aging have been derived from studies of mouse models. In this Review, we explore how well such models are applicable to understanding the aging process throughout the 80-100 years of human life and discuss recent advances in identifying and characterizing the mechanisms that underlie age-associated defective adaptive immunity in humans.

引用

页码：428 / 436

页数：9

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