Dendritic cell subsets in type 1 diabetes: friend or foe?

被引：39

作者：

Morel, Penelope A. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15261 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

dendritic cells; type; 1; diabetes; T regulatory cells; autoimmunity; tolerance; REGULATORY T-CELLS; PERIPHERAL LYMPHOID ORGANS; NECROSIS-FACTOR-ALPHA; NOD MICE; ANTIGEN PRESENTATION; STEADY-STATE; CUTTING EDGE; TGF-BETA; IN-VIVO; TREATMENT PREVENTS;

D O I：

10.3389/fimmu.2013.00415

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 1 diabetes (T1D) is a T cell mediated autoimmune disease characterized by immune mediated destruction of the insulin-producing beta cells in the islets of Langerhans. Dendritic cells (DC) have been implicated in the pathogenesis of T1D and are also used as immunotherapeutic agents. Plasmacytoid (p)DC have been shown to have both protective and pathogenic effects and a newly described merocytic DC population has been shown to break tolerance in the mouse model of Ti D, the non-obese diabetic (NOD) mouse. We have used DC populations to prevent the onset of T1D in NOD mice and clinical trials of DC therapy in T1D diabetes have been initiated. In this review we will critically examine the recent published literature on the role of DC subsets in the induction and regulation of the autoimmune response in T1D.

引用

页数：11

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