Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

被引：118

作者：

Ganesan, Palanivel ^{[1
,2
,3
]}

Ramalingam, Prakash ^{[4
,5
]}

Karthivashan, Govindarajan ^{[1
]}

Ko, Young Tag ^{[5
]}

Choi, Dong-Kug ^{[1
,2
,3
]}

机构：

[1] Konkuk Univ, Dept Biotechnol, Coll Biomed & Hlth Sci, Chungju 27478, South Korea

[2] Konkuk Univ, Nanotechnol Res Ctr, Chungju, South Korea

[3] Konkuk Univ, Dept Appl Life Sci, Chungju, South Korea

[4] Univ Sci, Philadelphia Coll Pharm, Dept Pharmaceut Sci, Philadelphia, PA USA

[5] Gachon Univ, Coll Pharm, Incheon, South Korea

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2018年 / 13卷

基金：

新加坡国家研究基金会;

关键词：

solid lipid nanoparticles; surface-modified solid lipid nanoparticles; chronic diseases; phyto-bioactive compounds; chitosan; BLOOD-BRAIN-BARRIER; PROOF-OF-CONCEPT; DRUG-DELIVERY; IN-VIVO; PARKINSON DISEASE; CELLULAR UPTAKE; OXIDATIVE STRESS; PHYSICOCHEMICAL CHARACTERIZATION; NEURODEGENERATIVE DISEASES; POLYMERIC NANOPARTICLES;

D O I：

10.2147/IJN.S155593

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer, obesity and neurodegenerative diseases. The multiple benefits of SLN delivery include improved stability, smaller particle size, leaching prevention and enhanced lymphatic uptake of the bioactive compounds through oral delivery. However, the burst release makes the SLN delivery systems inadequate for the oral delivery of various phyto-bioactive compounds that can treat such chronic diseases. Recently, the surface-modified SLN (SMSLN) was observed to overcome this limitation for oral delivery of phyto-bioactive compounds, and there is growing evidence of an enhanced uptake of curcumin delivered orally via SMSLNs in the brain. This review focuses on different SLN and SMSLN systems that are useful for oral delivery of phyto-bioactive compounds to treat various chronic diseases.

引用

页码：1569 / 1583

页数：15

共 197 条

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