Peripheral tissue homing receptor control of naive, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues

被引:33
|
作者
Brinkman, C. Colin [1 ]
Peske, J. David [1 ]
Engelhard, Victor Henry [1 ]
机构
[1] Univ Virginia, Sch Med, Dept Microbiol Immunol & Canc Biol, Carter Immunol Ctr, Charlottesville, VA 22908 USA
来源
FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷
关键词
T cell trafficking; T cell memory; T cell heterogeneity; tumor infiltrating lymphocytes; T cell migration; T cell recirculation; memory T cell trafficking; effector T cell migration; TUMOR-INFILTRATING LYMPHOCYTES; NODE-LIKE STRUCTURES; LT-ALPHA-BETA; DENDRITIC CELLS; L-SELECTIN; IN-VIVO; P-SELECTIN; ADHESION MOLECULE; BLOOD LYMPHOCYTES; IMMUNE CELLS;
D O I
10.3389/fimmu.2013.00241
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programing movement to sites of infection and injury. There are three major types of CD8 effector T cells based on homing receptor expression, which arise in distinct lymphoid organs. Recent publications indicate that naive, effector, and memory T cell migration is more complex than once thought; while many effectors enter peripheral tissues, some re-enter lymph nodes (LN), and contain central memory precursors. LN re-entry can depend on CD62L or peripheral tissue homing receptors. Memory T cells in LN tend to express the same homing receptors as their forebears, but often are CD62Lneg. Homing receptors also control CD8 T cell tumor entry. Tumor vasculature has low levels of many peripheral tissue homing receptor ligands, but portions of it resemble high endothelial venules (HEV), enabling naive T cell entry, activation, and subsequent effector activity. This vasculature is associated with positive prognoses in humans, suggesting it may sustain ongoing anti-tumor responses. These findings reveal new roles for homing receptors expressed by naive, effector, and memory CD8 T cells in controlling entry into lymphoid and non-lymphoid tissues.
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页数:8
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