On the Etiology of Incident Brain Lacunes Longitudinal Observations From the LADIS Study

被引：73

作者：

Gouw, Alida A. ^{[1
,3
]}

van der Flier, Wiesje M.

Pantoni, Leonardo ^{[4
]}

Inzitari, Domenico ^{[4
]}

Erkinjuntti, Timo ^{[5
]}

Wahlund, Lars O. ^{[6
]}

Waldemar, Gunhild ^{[7
]}

Schmidt, Reinhold ^{[8
,9
]}

Fazekas, Franz ^{[8
,9
]}

Scheltens, Philip

Barkhof, Frederik ^{[2
,3
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Radiol, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Image Anal Ctr, NL-1007 MB Amsterdam, Netherlands

[4] Univ Florence, Dept Neurol & Psychiat Sci, I-50121 Florence, Italy

[5] Univ Helsinki, Dept Clin Neurosci, Memory Res Unit, FIN-00014 Helsinki, Finland

[6] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Neurobiol, Care Sci & Soc, Huddinge, Sweden

[7] Copenhagen Univ Hosp, Dept Neurol, Memory Disorders Res Unit, Copenhagen, Denmark

[8] Med Univ, Dept Neurol, Graz, Austria

[9] Med Univ, MRI Inst, Graz, Austria

来源：

STROKE | 2008年 / 39卷 / 11期

关键词：

lacunes; white matter hyperintensities; MRI;

D O I：

10.1161/STROKEAHA.108.521807

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. Methods-Baseline and 3-year follow-up MRI were collected within the LADIS study (n = 358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. Results-106 incident lacunes were observed in 62 patients ( 58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P = 0.01) and were mostly accompanied by new and expanded WMH (P < 0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. Conclusion-Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region. (Stroke. 2008; 39: 3083-3085.)

引用

页码：3083 / 3085

页数：3

共 11 条

[1] Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging -: Risk factors, recurrence, and outcome in 175 consecutive cases [J].