Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

被引:305
作者
Li, Benhao [1 ]
Zhao, Mengyao [1 ]
Feng, Lishuai [2 ]
Dou, Chaoran [3 ]
Ding, Suwan [1 ,5 ]
Zhou, Gang [4 ]
Lu, Lingfei [1 ]
Zhang, Hongxin [1 ]
Chen, Feiya [1 ]
Li, Xiaomin [1 ]
Li, Guangfeng [4 ,5 ]
Zhao, Shichang [6 ]
Jiang, Chunyu [2 ]
Wang, Yan [3 ]
Zhao, Dongyuan [1 ]
Cheng, Yingsheng [2 ]
Zhang, Fan [1 ]
机构
[1] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat & iC, State Key Lab Mol Engn Polymers, Dept Chem, Shanghai 200433, Peoples R China
[2] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China
[3] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Inst Ultrasound Med, Dept Ultrasound Med, 600 Yishan Rd, Shanghai 200233, Peoples R China
[4] Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Adv Mat Lab, Shanghai 200438, Peoples R China
[5] Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Dept Macromol Sci, Shanghai 200438, Peoples R China
[6] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
BRAIN-BARRIER; BRIGHT;
D O I
10.1038/s41467-020-16924-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (similar to 5-60min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000nm. Thanks to the long blood circulation time (half-life of 3.2h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Optical bioimaging in the second near-infrared (NIR-II, 1000-1700nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes.
引用
收藏
页数:11
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