Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

被引：301

作者：

Li, Benhao ^{[1
]}

Zhao, Mengyao ^{[1
]}

Feng, Lishuai ^{[2
]}

Dou, Chaoran ^{[3
]}

Ding, Suwan ^{[1
,5
]}

Zhou, Gang ^{[4
]}

Lu, Lingfei ^{[1
]}

Zhang, Hongxin ^{[1
]}

Chen, Feiya ^{[1
]}

Li, Xiaomin ^{[1
]}

Li, Guangfeng ^{[4
,5
]}

Zhao, Shichang ^{[6
]}

Jiang, Chunyu ^{[2
]}

Wang, Yan ^{[3
]}

Zhao, Dongyuan ^{[1
]}

Cheng, Yingsheng ^{[2
]}

Zhang, Fan ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat & iC, State Key Lab Mol Engn Polymers, Dept Chem, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China

[3] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Inst Ultrasound Med, Dept Ultrasound Med, 600 Yishan Rd, Shanghai 200233, Peoples R China

[4] Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Adv Mat Lab, Shanghai 200438, Peoples R China

[5] Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Dept Macromol Sci, Shanghai 200438, Peoples R China

[6] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped, 600 Yishan Rd, Shanghai 200233, Peoples R China

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

BRAIN-BARRIER; BRIGHT;

D O I：

10.1038/s41467-020-16924-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (similar to 5-60min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000nm. Thanks to the long blood circulation time (half-life of 3.2h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Optical bioimaging in the second near-infrared (NIR-II, 1000-1700nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes.

引用

页数：11

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