Trans-generational influences of sulfamethoxazole on lifespan, reproduction and population growth of Caenorhabditis elegans

被引:40
作者
Yu, Zhenyang [1 ]
Sun, Guohua [3 ,4 ]
Liu, Yanjun [3 ,5 ]
Yin, Daqiang [1 ]
Zhang, Jing [2 ]
机构
[1] Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Key Lab Yangtze River Water Environm,Minist Educ, Shanghai 200092, Peoples R China
[2] Shanghai Inst Technol, Ecol Tech & Engn Coll, Shanghai 201418, Peoples R China
[3] Jinxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China
[4] Univ Ulsan, Dept Civil & Environm Engn, Ulsan 680748, South Korea
[5] Univ Oklahoma, Collage Engn, Sch Civil Engn & Environm Sci, Norman, OK 73019 USA
基金
中国国家自然科学基金; 瑞典研究理事会;
关键词
Trans-generational effect; Sulfamethoxazole; Lifespan; Reproduction; Population growth; Caenorhabditis elegans; EXPOSURE; TOXICITY; BEHAVIOR; SULFONAMIDES; INHIBITIONS; MICROBIOTA; EVOLUTION; HORMESIS; PROGENY; HEALTH;
D O I
10.1016/j.ecoenv.2016.10.017
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Trans-generational effects are increasingly used to indicate long-term influences of environmental pollutants. However, such studies can be complex and yield inconclusive results. In this study, the transgenerational effects of sulfamethoxazole (SMX) on Caenorhabditis elegans on lifespan, reproduction and population growth were tested for 7 consecutive generations, which included gestating generation (F0), embryo-exposed generation (F1), germline-exposed generation (F2), the first non -exposed generation (F3) and the three following generations (F4-F6). Results showed that lifespan was significantly affected by embryo exposure (F1) at 400 Inn SMX with a value as low as 47% of the control. The reproduction (a total brood size as 49% of the control) and population growth (81% of the control) were significantly affected in germline exposure (F2). Lifespan and reproduction were severely inhibited in non -exposed generations, confirming the real trans-generational effects. Notably, initial reproduction and reproduction duration showed opposite generation related changes, indicating their interplay in the overall brood size. The population growth rate was well correlated with median lethal time, brood size and initial reproduction, which indicated that the population would increase when the nematodes lived longer and reproduced more offspring within shorter duration.
引用
收藏
页码:312 / 318
页数:7
相关论文
共 40 条
[1]   The lifespan-reproduction trade-off under dietary restriction is sex-specific and context-dependent [J].
Adler, Margo I. ;
Cassidy, Elizabeth J. ;
Fricke, Claudia ;
Bonduriansky, Russell .
EXPERIMENTAL GERONTOLOGY, 2013, 48 (06) :539-548
[2]   Population modelling to compare chronic external radiotoxicity between individual and population endpoints in four taxonomic groups [J].
Alonzo, Frederic ;
Hertel-Aas, Turid ;
Real, Almudena ;
Lance, Emilie ;
Garcia-Sanchez, Laurent ;
Bradshaw, Clare ;
Vives i Baffle, Jordi ;
Oughton, Deborah H. ;
Garnier-Laplace, Jacqueline .
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY, 2016, 152 :46-59
[3]   Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health [J].
Babenko, Olena ;
Kovalchuk, Igor ;
Metz, Gerlinde A. S. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2015, 48 :70-91
[4]   Effects of the presence of sulfonamides in the environment and their influence on human health [J].
Baran, Wojciech ;
Adamek, Ewa ;
Ziemianska, Justyna ;
Sobczak, Andrzej .
JOURNAL OF HAZARDOUS MATERIALS, 2011, 196 :1-15
[5]   Nutrition and the science of disease prevention: a systems approach to support metabolic health [J].
Bennett, Brian J. ;
Hall, Kevin D. ;
Hu, Frank B. ;
McCartney, Anne L. ;
Roberto, Christina .
ANNALS REPORTS, VOL 1352, 2015, 1352 :1-12
[6]   Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna [J].
Bona, Mirco Dalla ;
Zounkova, Radka ;
Merlanti, Roberta ;
Blaha, Ludek ;
De Liguoro, Marco .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2015, 113 :152-158
[7]  
BRENNER S, 1974, GENETICS, V77, P71
[8]   Can environmental conditions experienced in early life influence future generations? [J].
Burton, Tim ;
Metcalfe, Neil B. .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 281 (1785)
[9]   Public Health Risks of Multiple-Drug-Resistant Enterococcus spp. in Southeast Asia [J].
Daniel, Diane Sunira ;
Lee, Sui Mae ;
Dykes, Gary A. ;
Rahman, Sadequr .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2015, 81 (18) :6090-6097
[10]  
Dhawan R, 2000, ENVIRON TOXICOL CHEM, V19, P3061, DOI [10.1897/1551-5028(2000)019<3061:ACOMIL>2.0.CO