Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection

被引：14

作者：

Chen, En-Qiang ^{[1
,3
]}

Sun, Hui ^{[1
,3
,4
]}

Feng, Ping ^{[1
,3
]}

Gong, Dao-Yin ^{[2
]}

Liu, Cong ^{[1
,3
]}

Bai, Lang ^{[1
,3
]}

Yang, Wen-Bing ^{[1
,3
]}

Lei, Xue-Zhong ^{[1
,3
]}

Chen, Li-Yu ^{[1
,3
]}

Huang, Fei-Jun ^{[2
]}

Tang, Hong ^{[1
,3
]}

机构：

[1] Sichuan Univ, Ctr Infect Dis, W China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China

[2] Sichuan Univ, Dept Forens Pathol, Coll Basic Med & Forens Med, Chengdu 610041, Sichuan Provinc, Peoples R China

[3] Sichuan Univ, Div Infect Dis, State Key Lab Biotherapy, Chengdu 610041, Sichuan Provinc, Peoples R China

[4] N Sichuan Med Coll, Dept Infect Dis, Nanchong 637000, Peoples R China

来源：

VIROLOGY JOURNAL | 2012年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Hepatocyte nuclear factor-4 alpha; Hepatocyte nuclear factor-3 beta; Chronic hepatitis B; Severe hepatitis B; Liver cirrhosis; Immunohistochemistry; HEPATITIS-B-VIRUS; HORMONE RECEPTORS; NATURAL-HISTORY; REPLICATION; TRANSCRIPTION; APOPTOSIS; LIVER;

D O I：

10.1186/1743-422X-9-23

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatocyte nuclear factors 4 alpha (HNF4 alpha) and 3 beta (HNF3 beta) are members of a group of liver enriched transcription factors (LETFs) that play important roles in regulating the replication of hepatitis B virus (HBV) and liver inflammation. However, the relationship of the level of HNF4 alpha and HNF3 beta with the severity of HBV-infected liver diseases is unclear. In this study, liver tissue samples from different types of HBV patients were collected, and HNF4 alpha and HNF3 beta expression were detected by immunohistochemistry. The expression of HNF4 alpha was significant higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) (both P < 0.05), but similar between patients with CHB and LC (P > 0.05). And the expression of HNF3 beta was similar among patients with CHB, LC and SHB (P > 0.05 for all pairwise comparison). This suggests that the expression level of HNF4 alpha was different in patients with different outcome of HBV infection, high expression level of HNF4 alpha may correlate with occurrence of SHB

引用

页数：5

共 20 条

[1] Hepatocyte nuclear factor 3β inhibits hepatitis B virus replication in vivo [J].