Cyclic dipeptides with 1-aminocyclopropane-1-carboxylic acid

被引：3
作者：
Kasafirek, E
Moural, J
Vinsova, J
Sturc, A
Taimr, J
机构：
[1] CHARLES UNIV,FAC PHARM,DEPT ORGAN & INORGAN CHEM,HRADEC KRALOVE 50005,CZECH REPUBLIC
[2] RES INST PHARM & BIOCHEM,CR-13060 PRAGUE 3,CZECH REPUBLIC
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1997年 / 62卷 / 06期
关键词：
dipeptides; 2,5-piperazinedione derivatives; 1-aminocyclopropane-1-carboxylic acid;
D O I：
10.1135/cccc19970941
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cyclic dipeptides of the formula cyclo(-Acc-X-), where Acc = 1-aminocyclopropane-1-carboxylic acid, X = Gly, Ala, Val, Leu, Phe or Tyr, were synthesized. The prepared 2,5-piperazinediones showed no proliferative or antiproliferative activity on normal human embryo cells as well as on HL60 leukemia cells. Results of trace memory assays in mice were negative.
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页码：941 / 947
页数：7
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