One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents

被引：97

作者：

Lock, Lye Lin ^{[1
,2
,3
]}

Lo, Yuguo ^{[4
]}

Mao, Xinpei ^{[2
,3
]}

Chen, Hanwei ^{[4
,9
]}

Staedtke, Verena ^{[5
]}

Bai, Renyuan ^{[6
]}

Ma, Wang ^{[1
]}

Lin, Ran ^{[2
,3
]}

Li, Yi ^{[2
,3
]}

Liu, Guanshu ^{[4
,10
]}

Cui, Honggang ^{[1
,2
,3
,7
,8
,11
]}

机构：

[1] Zhengzhou Univ, Dept Oncol, Affiliated Hosp 1, 1 Jianshe Eastern Rd, Zhengzhou 450052, Henan, Peoples R China

[2] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA

[4] Johns Hopkins Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Div MR Res, Baltimore, MD 21205 USA

[5] Johns Hopkins Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[6] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[7] Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[8] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA

[9] Panyu Cent Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China

[10] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD 21205 USA

[11] Johns Hopkins Univ, Wilmer Eye Inst, Ctr Nanomed, Sch Med, 400 North Broadway, Baltimore, MD 21231 USA

来源：

ACS NANO | 2017年 / 11卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

molecular assembly; supramolecular nanofibers; MRI; CEST; anticancer drugs; PEPTIDE AMPHIPHILE NANOFIBERS; IN-VIVO; DRUG-DELIVERY; PROTON-EXCHANGE; CONTRAST AGENTS; PH; MRI; DESIGN; ACID; NANOSTRUCTURES;

D O I：

10.1021/acsnano.6b07196

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in the clinic; however, safety concerns associated with their toxicities in the free ionic form have promoted the development of new generations of metal-free contrast agents. Here we report a supramolecular strategy to convert an FDA-approved anticancer drug, Pemetrexed (Pem), to a molecular hydrogelator with inherent chemical exchange saturation transfer (CEST) MRI signals. The rationally designed drug peptide conjugate can spontaneously associate into filamentous assemblies under physiological conditions and consequently form theranostic supra-molecular hydrogels for injectable delivery. We demonstrated that the local delivery and distribution of Pem peptide nanofiber hydrogels can be directly assessed using CEST MRI in a mouse glioma model. Our work lays out the foundation for the development of drug-constructed theranostic supramolecular materials with an inherent CEST MRI signal that enables noninvasive monitoring of their in vivo distribution and drug release.

引用

页码：797 / 805

页数：9

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