Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogues

被引：9

作者：

Wu, Zhimeng ^{[1
]}

Guo, Xueqing ^{[1
]}

Gu, Guofeng ^{[2
]}

Guo, Zhongwu ^{[1
,2
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 22期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PHOSPHORYLATED GPI ANCHOR; PROTEINS; SORTASE; BIOSYNTHESIS; PEPTIDE;

D O I：

10.1021/ol4028144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Analogs of the human CD52 and CO24 antigens carrying the common core structure of glycosylphosphatidylinositol (GPI) anchors and the intact polypeptide sequences of CD52 and CD24 were chemoenzymatically synthesized. CD52 and CD24 proteins were obtained by solid-phase peptide synthesis and then coupled to chemically synthesized GPI anchors under the influence of a bacterial enzyme, sortase A, to afford the target molecules in good yields.

引用

页码：5906 / 5908

页数：3