Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogues

被引：9

作者：

Wu, Zhimeng ^{[1
]}

Guo, Xueqing ^{[1
]}

Gu, Guofeng ^{[2
]}

Guo, Zhongwu ^{[1
,2
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 22期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PHOSPHORYLATED GPI ANCHOR; PROTEINS; SORTASE; BIOSYNTHESIS; PEPTIDE;

D O I：

10.1021/ol4028144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Analogs of the human CD52 and CO24 antigens carrying the common core structure of glycosylphosphatidylinositol (GPI) anchors and the intact polypeptide sequences of CD52 and CD24 were chemoenzymatically synthesized. CD52 and CD24 proteins were obtained by solid-phase peptide synthesis and then coupled to chemically synthesized GPI anchors under the influence of a bacterial enzyme, sortase A, to afford the target molecules in good yields.

引用

收藏

页码：5906 / 5908

页数：3

相关论文

共 36 条

[31] A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles [J].

Butler, Marcus O. ;

Ansen, Sascha ;

Tanaka, Makito ;

Imataki, Osamu ;

Berezovskaya, Alla ;

Mooney, Mary M. ;

Metzler, Genita ;

Milstein, Matthew I. ;

Nadler, Lee M. ;

Hirano, Naoto .

INTERNATIONAL IMMUNOLOGY, 2010, 22 (11) :863-873

[32] Branched multipeptide immunotherapy for glioblastoma using human leukocyte antigen-A*0201-restricted cytotoxic T-lymphocyte epitopes from ERBB2, BIRC5 and CD99 [J].

Kim, Young-Hee ;

Tran, Thi-Anh-Thuy ;

Lee, Hyun-Ju ;

Jung, Sook-In ;

Lee, Je-Jung ;

Jang, Wool-Youl ;

Moon, Kyung-Sub ;

Kim, In-Young ;

Jung, Shin ;

Jung, Tae-Young .

ONCOTARGET, 2016, 7 (31) :50535-50547

[33] Production and characterization of a chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells as a vaccine candidate against COVID-19 [J].

Lao, Thailin ;

Avalos, Ileanet ;

Rodriguez, Elsa Maria ;

Zamora, Yasser ;

Rodriguez, Alianet ;

Ramon, Ailyn ;

Alvarez, Yanitza ;

Cabrales, Ania ;

Andujar, Ivan ;

Gonzalez, Luis Javier ;

Puente, Pedro ;

Garcia, Cristina ;

Gomez, Leonardo ;

Valdes, Rodolfo ;

Estrada, Mario Pablo ;

Carpio, Yamila .

PLOS ONE, 2023, 18 (09)

[34] A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics: A study of human autoreactive CD4+T cells specific for GAD65 [J].

Oling, Viveka ;

Geubtner, Kelly ;

Ilonen, Jorma ;

Reijonen, Helena .

AUTOIMMUNITY, 2010, 43 (08) :573-582

[35] High-affinity human leucocyte antigen class I binding variola-derived peptides induce CD4+ T cell responses more than 30 years post-vaccinia virus vaccination [J].

Wang, M. ;

Tang, S. T. ;

Lund, O. ;

Dziegiel, M. H. ;

Buus, S. ;

Claesson, M. H. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2009, 155 (03) :441-446

[36] Extensive major histocompatibility complex class I binding promiscuity for Mycobacterium tuberculosis TB10.4 peptides and immune dominance of human leucocyte antigen (HLA)-B*0702 and HLA-B*0801 alleles in TB10.4 CD8+T-cell responses [J].

Axelsson-Robertson, Rebecca ;

Weichold, Frank ;

Sizemore, Donata ;

Wulf, Markus ;

Skeiky, Yasir A. W. ;

Sadoff, Jerry ;

Maeurer, Markus J. .

IMMUNOLOGY, 2010, 129 (04) :496-505

← 1 2 3 4 →