Glucose Metabolism during Resting State Reveals Abnormal Brain Networks Organization in the Alzheimer's Disease and Mild Cognitive Impairment

被引:85
作者
Sanabria-Diaz, Gretel [1 ]
Martinez-Montes, Eduardo [2 ]
Melie-Garcia, Lester [2 ]
机构
[1] Cuban Neurosci Ctr, Neurodiagnost Dept, Havana, Cuba
[2] Cuban Neurosci Ctr, Neuroinformat Dept, Havana, Cuba
基金
美国国家卫生研究院;
关键词
POSITRON-EMISSION-TOMOGRAPHY; FUNCTIONAL CONNECTIVITY; FDG-PET; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; CLINICAL-DIAGNOSIS; NATIONAL INSTITUTE; CORTICAL THICKNESS; LOW-FREQUENCY; DEMENTIA;
D O I
10.1371/journal.pone.0068860
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This paper aims to study the abnormal patterns of brain glucose metabolism co-variations in Alzheimer disease (AD) and Mild Cognitive Impairment (MCI) patients compared to Normal healthy controls (NC) using the Alzheimer Disease Neuroimaging Initiative (ADNI) database. The local cerebral metabolic rate for glucose (CMRgl) in a set of 90 structures belonging to the AAL atlas was obtained from Fluro-Deoxyglucose Positron Emission Tomography data in resting state. It is assumed that brain regions whose CMRgl values are significantly correlated are functionally associated; therefore, when metabolism is altered in a single region, the alteration will affect the metabolism of other brain areas with which it interrelates. The glucose metabolism network (represented by the matrix of the CMRgl co-variations among all pairs of structures) was studied using the graph theory framework. The highest concurrent fluctuations in CMRgl were basically identified between homologous cortical regions in all groups. Significant differences in CMRgl co-variations in AD and MCI groups as compared to NC were found. The AD and MCI patients showed aberrant patterns in comparison to NC subjects, as detected by global and local network properties (global and local efficiency, clustering index, and others). MCI network's attributes showed an intermediate position between NC and AD, corroborating it as a transitional stage from normal aging to Alzheimer disease. Our study is an attempt at exploring the complex association between glucose metabolism, CMRgl covariations and the attributes of the brain network organization in AD and MCI.
引用
收藏
页数:25
相关论文
共 127 条
[1]   A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs [J].
Achard, S ;
Salvador, R ;
Whitcher, B ;
Suckling, J ;
Bullmore, ET .
JOURNAL OF NEUROSCIENCE, 2006, 26 (01) :63-72
[2]  
Achard S, 2007, EFFICIENCY COST EC B
[3]   Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease [J].
Acosta-Cabronero, Julio ;
Williams, Guy B. ;
Pengas, George ;
Nestor, Peter J. .
BRAIN, 2010, 133 :529-539
[4]   Resting state fMRI in Alzheimer's disease: beyond the default mode network [J].
Agosta, Federica ;
Pievani, Michela ;
Geroldi, Cristina ;
Copetti, Massimiliano ;
Frisoni, Giovanni B. ;
Filippi, Massimo .
NEUROBIOLOGY OF AGING, 2012, 33 (08) :1564-1578
[5]  
Aleman-Gomez Y, 2006, IBASPM TOOLBOX AUTOM
[6]   Longitudinal PET evaluation of cerebral metabolic decline in dementia: A potential outcome measure in Alzheimer's disease treatment studies [J].
Alexander, GE ;
Chen, K ;
Pietrini, P ;
Rapoport, SI ;
Reiman, EM .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (05) :738-745
[7]  
[Anonymous], 1999, Small Worlds. The Dynamics of Networks Between Order and Randomness
[9]   Altered resting state complexity in schizophrenia [J].
Bassett, Danielle S. ;
Nelson, Brent G. ;
Mueller, Bryon A. ;
Camchong, Jazmin ;
Lim, Kelvin O. .
NEUROIMAGE, 2012, 59 (03) :2196-2207
[10]   Small-world brain networks [J].
Bassett, Danielle Smith ;
Bullmore, Edward T. .
NEUROSCIENTIST, 2006, 12 (06) :512-523