Diagnosis of Zollinger-Ellison syndrome: Increasingly difficult

被引：52
作者：
Ito, Tetsuhide [2 ]
Cadiot, Guillaume [3 ]
Jensen, Robert T. [1 ]
机构：
[1] NIDDK, Digest Dis Branch, NIH, Bethesda, MD 20892 USA
[2] Kyushu Univ, Dept Med & Bioregulatory Sci, Grad Sch Med Sci, Fukuoka 8128582, Japan
[3] Hosp Robert Debre, Serv Hepatogastroenterol, Ctr Hosp Univ Reims, F-51092 Reims, France
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2012年 / 18卷 / 39期
关键词：
Zollinger-Ellison syndrome; Gastrinoma; Hypergastrinemia; Secretin test; Serum gastrin; Gastrin; Neuroendocrine tumor; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; PANCREATIC ENDOCRINE TUMORS; SERUM CHROMOGRANIN-A; PROTON-PUMP INHIBITORS; INSTITUTES-OF-HEALTH; NEOPLASIA-TYPE-I; LONG-TERM; GASTRIN-CONCENTRATIONS; NEUROENDOCRINE-TUMORS; SYSTEMIC MASTOCYTOSIS;
D O I：
10.3748/wjg.v18.i39.5495
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management. (C) 2012 Baishideng. All rights reserved.
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页码：5495 / 5503
页数：9
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