Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation Report of 2 cases

被引:16
作者
Mano, Yui [1 ]
Kumabe, Toshihiro [1 ]
Shibahara, Ichiyo [1 ]
Saito, Ryuta [1 ]
Sonoda, Yukihiko [1 ]
Watanabe, Mika [2 ]
Tominaga, Teiji [1 ]
机构
[1] Tohoku Univ, Grad Sch Med, Dept Neurosurg, Sendai, Miyagi 9808574, Japan
[2] Tohoku Univ Hosp, Dept Pathol, Sendai, Miyagi, Japan
基金
日本学术振兴会;
关键词
dysembryoplastic neuroepithelial tumor; oncology; magnetic resonance imaging; malignant transformation; recurrence; RARE;
D O I
10.3171/2013.1.PEDS11449
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Dysembryoplastic neuroepithelial tumors (DNETs) have conventionally been regarded as benign and stable tumors and considered curable with surgery without adjunctive therapy. Recently, recurrent DNETs with or without malignant transformation have been described. The authors report 2 unusual cases of DNET: 1) an enlarging lesion that developed an enhancing component over the natural course of 4 years, and 2) a recurrent DNET that developed an enhancing component 10-11 years after gross-total resection. The patient in the first case was treated with subtotal resection and adjuvant radiochemotherapy; histological examination of the tumor led to the diagnosis of DNET, WHO Grade I, for the nonenhancing component and anaplastic oligodendroglioma, WHO Grade III, for the enhancing component. The patient in the second case was treated with repeat gross-total resection; the original tumor had been histologically diagnosed as DNET, and the nonenhancing and enhancing components of the recurrent tumor were diagnosed as simple and complex forms of DNET, respectively. These and previous reports suggest an aggressive subtype of DNETs. If follow-up MRI reveals progressive behavior, resection should be performed without delay. Additional radiochemotherapy is needed if the histological diagnosis demonstrates malignant transformation. (http://thejns.org/doi/abs/10.3171/2013.1.PEDS11449)
引用
收藏
页码:518 / 525
页数:8
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