It is well known that in single step breaking of R-parity conserving SUSY SO(10) that needs the Higgs representations 126 circle plus 126, the GUT gauge coupling violates the perturbative constraint at mass scales a few times larger than the GUT scale. Therefore, if the SO(10) gauge coupling is to remain perturbative up to the Planck scale (equivalent to 2 x 10(18) GeV), the scale M-U of the CUT symmetry breaking is to be bounded from below. The bound depends upon specific Higgs representations used for SO(10) symmetry breaking but, as we find, cannot be lower than 1.5 X 10(17) GeV. In order to obtain such a high unification scale we propose a two-step SO(10) breaking through SU(2)(L) x SU(2)(R) X U(1)(B-L) x SU(3)c (g(2L) not equal g(2R)) intermediate gauge symmetry.,W estimate the potential threshold and gravitational corrections to the gauge coupling running and show that they can make the picture of perturbative gauge coupling running consistent at least up to the Planck scale. We also show that when SO(10) -> G(2213) by the Higgs representations 210 circle plus 541 gravitational corrections alone with negligible threshold effects may guarantee such perturbative gauge coupling. The lifetime of the proton is found to increase by nearly 6 orders over the present experimental limit for rho -> e(+)pi(0). For the proton decay mediated by a dim = 5 operator a wide range of lifetimes is possible, extending from the current experimental limit up to values 2-3 orders longer.