A Sensitive Simultaneous Determination of L-Dopa and Acetaminophen on a Glassy Carbon Electrode Modifed with a Film of SWCNT-CHIT-IL Nanocomposite

被引：5

作者：

Babaei, Ali ^{[1
,2
]}

Babazadeh, Mitra ^{[1
]}

Afrasiabi, Mohammad ^{[3
]}

机构：

[1] Arak Univ, Dept Chem, Arak 3815688349, Iran

[2] Arak Univ, Res Ctr Nanotechnol, Arak 3815688349, Iran

[3] Islamic Azad Univ, Young Researchers Club, Shoushtar Branch, Shoushtar 6451741117, Iran

来源：

SENSOR LETTERS | 2012年 / 10卷 / 3-4期

关键词：

L-Dopa; Acetaminophen; Single-Walled Carbon Nanotubes; Chitosan; Ionic Liquid; TEMPERATURE IONIC LIQUID; KINETIC-SPECTROPHOTOMETRIC DETERMINATION; DIRECT ELECTROCHEMISTRY; VOLTAMMETRIC DETERMINATION; FLOW-INJECTION; HUMAN PLASMA; DERIVATIVE SPECTROPHOTOMETRY; PHARMACEUTICAL FORMULATIONS; NANOTUBES COMPOSITE; PASTE ELECTRODE;

D O I：

10.1166/sl.2012.2327

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The electro-oxidation of 3,4-dihydroxyphenylalanine (L-dopa) and acetaminophen (Acet) has been investigated by the application of single-walled carbon nanotube/chitosan/ionic liquid modified glassy carbon electrode (SWCNT-CHIT-IUGCE) using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) methods. The modified electrode worked as an efficient electron-mediator for L-dopa and Acet. The DPV data showed that the obtained anodic peak currents were linearly dependent on the L-dopa and Acet concentrations in the range of 2-450 mu M and 1-420 mu M, respectively. The fabricated sensor revealed some advantages such as convenient preparation, high sensitivity, good repeatability and stability. The experimental results revealed that SWCNT-CHIT-IUGCE could be successfully employed as an electrochemical sensor for the simultaneous determination of L-dopa and Acet in human serum and urine.

引用

页码：993 / 999

页数：7

共 57 条

[21] Two-dimensional liquid chromatography-ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma Application to a pharmacokinetic study [J].