Cycloaddition of Chiral tert-Butanesulfinimines with Trimethylenemethane

被引：33
|
作者：
Procopiou, George [1 ]
Lewis, William [1 ]
Harbottle, Gareth [2 ]
Stockman, Robert A. [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 08期
基金：
英国工程与自然科学研究理事会;
关键词：
ASYMMETRIC 3+2 CYCLOADDITION; SULFINIMINES;
D O I：
10.1021/ol400720b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.
引用
收藏
页码：2030 / 2033
页数：4
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