Cycloaddition of Chiral tert-Butanesulfinimines with Trimethylenemethane

被引：33

作者：

Procopiou, George ^{[1
]}

Lewis, William ^{[1
]}

Harbottle, Gareth ^{[2
]}

Stockman, Robert A. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 08期

基金：

英国工程与自然科学研究理事会;

关键词：

ASYMMETRIC 3+2 CYCLOADDITION; SULFINIMINES;

D O I：

10.1021/ol400720b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.

引用

页码：2030 / 2033

页数：4

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