Ambient PM2.5 air pollution exposure and hepatocellular carcinoma incidence in the United States

被引:58
作者
Trang VoPham [1 ,2 ,3 ]
Bertrand, Kimberly A. [4 ]
Tamimi, Rulla M. [1 ,2 ,3 ]
Laden, Francine [1 ,2 ,3 ,5 ]
Hart, Jaime E. [2 ,3 ,5 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA
[3] Harvard Med Sch, 181 Longwood Ave, Boston, MA 02115 USA
[4] Boston Univ, Slone Epidemiol Ctr, 72 East Concord St, Boston, MA 02118 USA
[5] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, 677 Huntington Ave, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
PM2.5; Particulate matter; Air pollution; Liver cancer; Hepatocellular carcinoma; Geographic information system; FINE PARTICULATE MATTER; HODGKIN-LYMPHOMA SUBTYPES; LIVER-CANCER INCIDENCE; LUNG-CANCER; ULTRAVIOLET-RADIATION; SOCIOECONOMIC-STATUS; DIABETES PREVALENCE; US COUNTIES; RISK; HEALTH;
D O I
10.1007/s10552-018-1036-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To conduct the first epidemiologic study prospectively examining the association between particulate matter air pollution < 2.5 A mu m in diameter (PM2.5) exposure and hepatocellular carcinoma (HCC) risk in the U.S. Surveillance, Epidemiology, and End Results (SEER) provided information on HCC cases diagnosed between 2000 and 2014 from 16 population-based cancer registries across the U.S. Ambient PM2.5 exposure was estimated by linking the SEER county with a spatial PM2.5 model using a geographic information system. Poisson regression with robust variance estimation was used to calculate incidence rate ratios and 95% confidence intervals (CIs) for the association between ambient PM2.5 exposure per 10 A mu g/m(3) increase and HCC risk adjusting for individual-level age at diagnosis, sex, race, year of diagnosis, SEER registry, and county-level information on health conditions, lifestyle, demographic, socioeconomic, and environmental factors. Higher levels of ambient PM2.5 exposure were associated with a statistically significant increased risk for HCC (n = 56,245 cases; adjusted IRR per 10 A mu g/m(3) increase = 1.26, 95% CI 1.08, 1.47; p < 0.01). If confirmed in studies with individual-level PM2.5 exposure and risk factor information, these results suggest that ambient PM2.5 exposure may be a risk factor for HCC in the U.S.
引用
收藏
页码:563 / 572
页数:10
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