Conserved non-coding elements and cis regulation: actions speak louder than words

被引：44

作者：

Nelson, Andrew C. ^{[1
]}

Wardle, Fiona C. ^{[1
]}

机构：

[1] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England

来源：

DEVELOPMENT | 2013年 / 140卷 / 07期

基金：

英国医学研究理事会;

关键词：

ChIP; Conserved non-coding elements; Cis regulation; Enhancer assay; Phylotypic stage; TRANSCRIPTION FACTOR-BINDING; KEY DEVELOPMENTAL GENES; IN-VIVO; ULTRACONSERVED ELEMENTS; EVOLUTIONARY DYNAMICS; CHROMATIN SIGNATURES; TEMPORAL MAP; EXPRESSION; ENHANCERS; GENOME;

D O I：

10.1242/dev.084459

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is a truth (almost) universally acknowledged that conserved non-coding genomic sequences function in the cis regulation of neighbouring genes. But is this a misconception? The literature is strewn with examples of conserved non-coding sequences being able to drive reporter expression, but the extent to which such sequences are actually used endogenously in vivo is only now being rigorously explored using unbiased genome-scale approaches. Here, we review the emerging picture, examining the extent to which conserved non-coding sequences equivalently regulate gene expression in different species, or at different developmental stages, and how genomics approaches are revealing the relationship between sequence conservation and functional use of cis-regulatory elements.

引用

页码：1385 / 1395

页数：11

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