Antimicrobial resistance among Brazilian Corynebacterium diphtheriae strains

被引：30

作者：

Pereira, Gabriela Andrade ^{[1
]}

Pimenta, Fabricia Pires ^{[2
]}

Wink dos Santos, Fatima Rejane ^{[3
]}

Damasco, Paulo Vieira ^{[4
]}

Hirata Junior, Raphael ^{[2
]}

Mattos-Guaraldi, Ana Luiza ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo Goes, Rio De Janeiro, Brazil

[2] Univ Estado Rio de Janeiro, Fac Ciencias Med, Disciplina Microbiol & Imunol, BR-20551030 Rio De Janeiro, Brazil

[3] Lab Cent Noel Nutels, Serv Bacteriol, Rio De Janeiro, Brazil

[4] Univ Fed Estado Rio De Janeiro, Dept Med Geral, Rio De Janeiro, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2008年 / 103卷 / 05期

关键词：

Corynebacterium diphtheriae; multiresistance; penicillin; antibiotics;

D O I：

10.1590/S0074-02762008000500019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The increasing problems with multidrug resistance in relation to Corynebacterium, including C. diphtheriae, are examples of challenges confronting many countries. For this reason, Brazilian C. diphtheriae strains were evaluated by the E-Test for their susceptibility to nine antibacterial drugs used in therapy. Resistance (MIC < 0.002; 0.38 mu g/ml) to penicillin G was found in 14.8% of the strains tested. Although erythromycin (MIC90 0.75 mu g/ml) and azithromycin (MIC90 0.064 mu g/ml) were active against C. diphtheriae in this study, 4.2% of the strains showed decreased susceptibility (MIC 1.0 mu g/ml) to erythromycin. Multiple resistance profiles were determined by the disk diffusion method using 31 antibiotics. Most C. diphtheriae strains (95.74%) showed resistance to mupirocin, aztreonam, ceftazidime, and/or oxacillin, ampicillin, penicillin, tetracycline, clindamycin, lincomycin, and erythromycin. This study presents the antimicrobial susceptibility profiles of Brazilian C. diphtheriae isolates. The data are of value to practitioners, and suggest that some concern exists regarding the use of penicillin.

引用

页码：507 / 510

页数：4

共 23 条

[1]

*CLSI, 2006, M45A CLSI, P18

[2] Comparison of phenotypic and genotypic methods for detection of diphtheria toxin among isolates of pathogenic corynebacteria [J].

Efstratiou, A ;

Engler, KH ;

Dawes, CS ;

Sesardic, D .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (11) :3173-3177

[3]

FORMIGA LCD, 1971, BRAZ J MICROBIOL, V2, P117

[4] EVALUATION OF API CORYNE IN COMPARISON WITH CONVENTIONAL METHODS FOR IDENTIFYING CORYNEFORM BACTERIA [J].

FRENEY, J ;

DUPERRON, MT ;

COURTIER, C ;

HANSEN, W ;

ALLARD, F ;

BOEUFGRAS, JM ;

MONGET, D ;

FLEURETTE, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (01) :38-41

[5] Antimicrobial susceptibility patterns of some recently established coryneform bacteria [J].

Funke, G ;

Punter, V ;

vonGraevenitz, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (12) :2874-2878

[6]

Gladin D. P., 1999, Antibiotiki i Khimioterapiya, V44, P17

[7] Linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft tissue bite infections in humans [J].

Goldstein, EJC ;

Citron, DM ;

Merriam, CV .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1469-1474

[8]

GRUNER E, 1992, MED MICROBIOL LETT, V1, P160

[9] Penicillin vs. erythromycin in the treatment of diphtheria [J].

Kneen, R ;

Giao, PN ;

Solomon, T ;

Tran, TMV ;

Nguyen, TTH ;

Long, TB ;

Wain, J ;

Day, NPJ ;

Hien, TT ;

Parry, CM ;

White, NJ .

CLINICAL INFECTIOUS DISEASES, 1998, 27 (04) :845-850

[10] THE IN-VITRO SUSCEPTIBILITIES OF TOXIGENIC STRAINS OF CORYNEBACTERIUM-DIPHTHERIAE ISOLATED IN NORTHWESTERN RUSSIA AND SURROUNDING AREAS TO 10 ANTIBIOTICS [J].

MAPLE, PAC ;

EFSTRATIOU, A ;

TSENEVA, G ;

RIKUSHIN, Y ;

DESHEVOI, S ;

JAHKOLA, M ;

VUOPIOVARKILA, J ;

GEORGE, RC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (06) :1037-1040

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