Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease

被引：15
作者：
Li, Xi [1 ]
Li, Ming [1 ]
Li, Yuan [2 ]
Quan, Qiankun [3 ]
Wang, Juan [4 ]
机构：
[1] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 2, Dept Geriatr, Xian 710004, Shaanxi Provinc, Peoples R China
[2] Xian Elect Power Cent Hosp, Dept Encephalopathy, Xian 710032, Shaanxi Provinc, Peoples R China
[3] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Res Ctr Rehabil Sci & Technol, Xian 710049, Shaanxi Provinc, Peoples R China
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Lab Med, Xian 710032, Shaanxi Provinc, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 36期
关键词：
Alzheimer's disease; ginsenoside Rg1; okadaic acid; phosphorylated Tau protein; brain-derived neurotrophic factor; traditional Chinese medicine; neural regeneration; NEUROTROPHIC FACTOR; INDUCED APOPTOSIS; TAU-PROTEIN; PHOSPHORYLATION; HYPERPHOSPHORYLATION; IMPAIRMENT; BINDING; KINASE; MODEL; BDNF;
D O I：
10.3969/j.issn.1673-5374.2012.36.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and established brain slice models of Alzheimer's disease induced by okadaic acid. The results revealed that ginsenoside Rg1 pretreatment suppressed the increase in phosphorylated Tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rg1 upregulates brain-derived neurotrophic factor expression and inhibits Tau protein phosphorylation in brain slices from a rat model of Alzheimer's disease.
引用
收藏
页码：2860 / 2866
页数：7
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