Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury

被引：61

作者：

Pan, Yihang ^{[1
]}

Wang, Xueke ^{[1
]}

Liu, Xiwang ^{[2
]}

Shen, Lihua ^{[1
]}

Chen, Qixing ^{[1
,3
]}

Shu, Qiang ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Natl Clin Res Ctr Child Hlth, Sch Med, Dept Clin Res Ctr,Childrens Hosp, Hangzhou 310052, Peoples R China

[2] Zhejiang Univ, Childrens Hosp, Sch Med, Dept Thorac & Cardiovasc Surg, Hangzhou 310003, Peoples R China

[3] Key Lab Diag & Treatment Neonatal Dis Zhejiang Pr, Hangzhou 310052, Peoples R China

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

ischemia-reperfusion injury; ferroptosis; iron; antioxidant; therapeutic strategies; CEREBRAL-ARTERY OCCLUSION; CELL-DEATH; PROMOTES FERROPTOSIS; LIPID-PEROXIDATION; RAT MODEL; IN-VIVO; IRON; ACTIVATION; KIDNEY; DAMAGE;

D O I：

10.3390/antiox11112196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that contributes to pathological damage in various conditions, including ischemic stroke, myocardial infarction, acute lung injury, liver transplantation, acute kidney injury and hemorrhagic shock. I/R damage is often irreversible, and current treatments for I/R injury are limited. Ferroptosis, a type of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides, has been implicated in multiple diseases, including I/R injury. Emerging evidence suggests that ferroptosis can serve as a therapeutic target to alleviate I/R injury, and pharmacological strategies targeting ferroptosis have been developed in I/R models. Here, we systematically summarize recent advances in research on ferroptosis in I/R injury and provide a comprehensive analysis of ferroptosis-regulated genes investigated in the context of I/R, as well as the therapeutic applications of ferroptosis regulators, to provide insights into developing therapeutic strategies for this devastating disease.

引用

页数：25

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