Peri-implant osseointegration after low-level laser therapy: micro-computed tomography and resonance frequency analysis in an animal model

被引:22
作者
Mayer, Luciano [1 ,2 ]
Gomes, Fernando Vacilotto [3 ]
de Oliveira, Marilia Gerhardt [4 ]
Duarte de Moraes, Joo Feliz [5 ]
Carlsson, Lennart [6 ]
机构
[1] Univ Fed Bahia UFBA, Ave Araujo Pinho, BR-40110912 Salvador, BA, Brazil
[2] Assoc Gaucha Ortodontia AGOR, Grad Program Implant Therapy, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande UFRGS, Sch Dent, Surg & Orthopaed Dept, Porto Alegre, RS, Brazil
[4] Natl Council Sci & Technol Dev CNPq, GHC, Porto Alegre, RS, Brazil
[5] Univ Fed Rio Grande do Sul, Sch Math, Porto Alegre, RS, Brazil
[6] Zimmer Dent Sweden, Res & Dev, Ind 4, S-43361 Gothenburg, Sweden
关键词
Dental implants; Low-level laser therapy; Micro-computed tomography; Osseointegration; DENTAL IMPLANTS; TITANIUM IMPLANT; BONE-FORMATION; RABBIT MODEL; PLACEMENT; STABILITY; TISSUE; RATS; PHOTOBIOMODULATION; SITES;
D O I
10.1007/s10103-016-2051-3
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The purpose of the present study is to evaluate the effects of low-level laser therapy on the osseointegration process by comparing resonance frequency analysis measurements performed at implant placement and after 30 days and micro-computed tomography images in irradiated vs nonirradiated rabbits. Fourteen male New Zealand rabbits were randomly divided into two groups of seven animals each, one control group (nonirradiated animals) and one experimental group that received low-level laser therapy (Thera LaseA (R), aluminum-gallium-arsenide laser diode, 10 J per spot, two spots per session, seven sessions, 830 nm, 50 mW, CW, 0.0028 cm(2)). The mandibular left incisor was surgically extracted in all animals, and one osseointegrated implant was placed immediately afterward (3.25o Au 11.5 mm; NanoTite, BIOMET 3i). Resonance frequency analysis was performed with the OsstellA (R) device at implant placement and at 30 days (immediately before euthanasia). Micro-computed tomography analyses were then conducted using a high-resolution scanner (SkyScan 1172 X-ray Micro-CT) to evaluate the amount of newly formed bone around the implants. Irradiated animals showed significantly higher implant stability quotients at 30 days (64.286 A +/- 1.596; 95 % confidence interval (CI) 60.808-67.764) than controls (56.357 A +/- 1.596; 95 %CI 52.879-59.835) (P = .000). The percentage of newly formed bone around the implants was also significantly higher in irradiated animals (75.523 A +/- 8.510; 95 %CI 61.893-89.155) than in controls (55.012 A +/- 19.840; 95 %CI 41.380-68.643) (P = .027). Laser therapy, based on the irradiation protocol used in this study, was able to provide greater implant stability and increase the volume of peri-implant newly formed bone, indicating that laser irradiation effected an improvement in the osseointegration process.
引用
收藏
页码:1789 / 1795
页数:7
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