Principles and Applications of Force Spectroscopy Using Atomic Force Microscopy

被引：11
作者：
Kim, Youngkyu [1 ,2 ]
Kim, Woong [1 ]
Park, Joon Won [1 ]
机构：
[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 37673, South Korea
[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2016年 / 37卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
Atomic force microscope; Force spectroscopy; Single-molecule biochemistry; Single-molecule detection; Super-resolution imaging; SINGLE-MOLECULE; SPRING CONSTANT; NONSPECIFIC INTERACTION; RECOGNITION EVENTS; MESSENGER-RNA; DNA; SURFACE; AFM; BOND; ANTIBODY;
D O I：
10.1002/bkcs.11022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Single-molecule force spectroscopy is a powerful technique for addressing single molecules. Unseen structures and dynamics of molecules have been elucidated using force spectroscopy. Atomic force microscope (AFM)-based force spectroscopy studies have provided picoNewton force resolution, subnanometer spatial resolution, stiffness of substrates, elasticity of polymers, and thermodynamics and kinetics of single-molecular interactions. In addition, AFM has enabled mapping the distribution of individual molecules in situ, and the quantification of single molecules has been made possible without modification or labeling. In this review, we describe the basic principles, sample preparation, data analysis, and applications of AFM-based force spectroscopy and its future.
引用
收藏
页码：1895 / 1907
页数：13
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