Synthesis, Spectroscopic, and Biological Studies on New Zirconium(IV) Porphyrins with Axial Ligand

被引：17

作者：

Bajju, Gauri D. ^{[1
]}

Devi, Gita ^{[1
]}

Katoch, Sapna ^{[1
]}

Bhagat, Madhulika ^{[2
]}

Deepmala ^{[1
]}

Ashu ^{[1
]}

Kundan, Sujata ^{[1
]}

Anand, Sunil Kumar ^{[1
]}

机构：

[1] Univ Jammu, PG Dept Chem, Jammu 180006, Jammu & Kashmir, India

[2] Univ Jammu, Sch Biotechnol, Jammu 180006, Jammu & Kashmir, India

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2013年 / 2013卷

关键词：

SPECTRAL PROPERTIES; METALLOPORPHYRINS; PHTHALOCYANINES; HAFNIUM(IV); COMPLEXES; APOPTOSIS; ACIDS;

D O I：

10.1155/2013/903616

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of parasubstituted tetraphenylporphyrin zirconium(IV) salicylate complexes (SA/5-SSAZr(IV)RTPP, R = p-H, p-CH3, p-NO2, p-Cl, SA = salicylate, and 5-SSA = 5-sulfosalicylate) have been synthesized, and the spectral properties of free base porphyrins, their corresponding metallated, and axially ligated zirconium(IV) porphyrin compounds were compared with each other. A detailed analysis of ultraviolet-visible (UV-vis), proton nulcear magnetic resonance (H-1 NMR) spectroscopy, infrared (IR) spectroscopy, and elemental analysis suggested the transformation from free base porphyrins to zirconium(IV) porphyrins. The ability of the metal in this complex for extra coordination of solvent molecules was confirmed by ESI-MS spectra. Besides the fluorescence, cyclic voltammetry, and thermogravimetric studies, the complexes were also screened for antimicrobial and anticancer activities. Among all the complexes, 5-SSAZr(p-NO2TPP) shows high antibacterial activity.

引用

页数：15

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