Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy

被引：64

作者：

Cavo, Marta ^{[1
]}

Serio, Francesca ^{[1
,2
]}

Kale, Narendra R. ^{[3
]}

D'Amone, Eliana ^{[1
]}

Gigli, Giuseppe ^{[1
,2
]}

del Mercato, Loretta L. ^{[1
]}

机构：

[1] Natl Res Council CNR NANOTEC, Inst Nanotechnol, C Campus Ecotekne,Via Monteroni, I-73100 Lecce, Italy

[2] Univ Salento, Dept Math & Phys Ennio De Giorgi, Via Arnesano, I-73100 Lecce, Italy

[3] MIT WPU, Sch Pharm, Pune 411038, Maharashtra, India

来源：

BIOMATERIALS SCIENCE | 2020年 / 8卷 / 18期

基金：

欧洲研究理事会;

关键词：

EXTRACELLULAR-MATRIX; CONTROLLED-RELEASE; DRUG-DELIVERY; POLY(EPSILON-CAPROLACTONE) NANOFIBERS; 3-DIMENSIONAL CULTURE; SILICA NANOPARTICLES; COMPOSITE SCAFFOLDS; CARBON NANOTUBES; RNA INTERFERENCE; VASCULAR GRAFTS;

D O I：

10.1039/d0bm00390e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Electrospinning is historically related to tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that are extremely similar to those of the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modelling and as patches for in vivo therapeutic delivery. In this review, we examine electrospinning by providing a brief description of the process and overview of most materials used in this process, discussing the effect of changing the process parameters on fiber conformations and assemblies. Then, we describe two different applications of electrospinning in service of cancer research: firstly, as three-dimensional (3D) fibrous materials for generating in vitro pre-clinical cancer models; and secondly, as patches encapsulating anticancer agents for in vivo delivery.

引用

页码：4887 / 4905

页数：19

共 181 条

[1] Cdk2 Silencing via a DNA/PCL Electrospun Scaffold Suppresses Proliferation and Increases Death of Breast Cancer Cells [J].

Achille, Clement ;

Sundaresh, Sowmya ;

Chu, Benjamin ;

Hadjiargyrou, Michael .

PLOS ONE, 2012, 7 (12)

[2]

Agrahari V., 2017, Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices, P189, DOI [DOI 10.1016/B978-0-323-42978-8.00009-7, 10.1016/B978-0-323-42978-8.00009-7]

[3] Engineered small diameter vascular grafts by combining cell sheet engineering and electrospinning technology [J].