Effectiveness of HIV Risk Reduction Interventions among Men who have Sex with Men in China: A Systematic Review and Meta-Analysis

被引:35
作者
Lu, Hongyan [1 ]
Liu, Yu [2 ]
Dahiya, Kapil [3 ]
Qian, Han-Zhu [2 ,4 ]
Fan, Wensheng [3 ]
Zhang, Li [1 ]
Ma, Juntao [5 ]
Ruan, Yuhua [6 ,7 ,8 ]
Shao, Yiming [6 ,7 ,8 ]
Vermund, Sten H. [2 ,9 ]
Yin, Lu [2 ]
机构
[1] Beijing Ctr Dis Prevent & Control, Inst AIDS STD Prevent & Control, Beijing, Peoples R China
[2] Vanderbilt Univ, Sch Med, Vanderbilt Inst Global Hlth, Nashville, TN 37212 USA
[3] Western Kentucky Univ, Coll Hlth & Human Serv, Dept Publ Hlth, Bowling Green, KY 42101 USA
[4] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA
[5] Chinese Peoples Liberat Army, Med Lib, Beijing, Peoples R China
[6] Chinese Ctr Dis Control & Prevent China CDC, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
[7] Chinese Ctr Dis Control & Prevent China CDC, Natl Ctr AIDS STD Control & Prevent NCAIDS, Beijing, Peoples R China
[8] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
[9] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA
来源
PLOS ONE | 2013年 / 8卷 / 08期
基金
美国国家卫生研究院;
关键词
PREVENTION INTERVENTIONS; DEVELOPING-COUNTRIES; BEHAVIORS; PREVALENCE; INFECTION; TRANSMISSION; EFFICACY; MSM;
D O I
10.1371/journal.pone.0072747
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective: To evaluate the effect of risk reduction interventions on HIV knowledge, attitudes and behaviors among men who have sex with men (MSM) in China. Methods: We performed a systematic review and meta-analysis of HIV risk reduction intervention studies among Chinese MSM. The summary difference of standardized mean differences (SMD) between both study arms or between pre- and post-intervention assessments were defined as the effect size (ES); ES was calculated using standard meta-analysis in random effects models. Results: Thirty-four eligible studies were included in the analysis, including two randomized clinical trials (RCT), six quasi-experimental studies, six pre-and-post intervention studies, and twenty serial cross-sectional intervention studies. These studies showed an increase in consistent condom use with any male sexual partners (mean ES, 0.46; 95% confidence interval [CI], 0.35-0.56), with regular sexual partners (mean ES, 0.41; 95% CI, 0.18-0.63), and casual sexual partners (mean ES, 0.52; 95% CI, 0.24-0.79). The analysis of ten studies that measured the impact on uptake of HIV testing also showed a positive result (mean ES, 0.55; 95% CI, 0.38-0.71). The risk reduction interventions also improved HIV/AIDS-related knowledge (mean ES, 0.77; 95% CI, 0.60-0.94) and attitudes (mean ES, 1.35; 95% CI, 0.91-1.79), but did not reduce prevalence of HIV (mean ES, 0.23; 95% CI, 0.02-0.45) and syphilis infections (mean ES, -0.01; 95% CI, -0.19-0.17). There was significant heterogeneity among these studies. Conclusions: On aggregate, HIV risk reduction interventions were effective in reducing risky behaviors and improving knowledge and attitudes among Chinese MSM, but were not associated with a change in the prevalence of HIV and syphilis. Future studies should use incidence as definitive study outcome.
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页数:15
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