Epigenetic Regulation of Regulatory T Cells in Kidney Disease and Transplantation

被引：5
作者：
Liu, Yufeng [1 ]
Peng, Bo [2 ]
Wu, Shengdi [3 ,4 ]
Xu, Nuo [5 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Dept Nursing, Gen Surg, Shanghai 200032, Peoples R China
[2] Cent S Univ, Xiangya Hosp 3, Transplantat Ctr, Changsha 410013, Hunan, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol & Hepatol, Shanghai 200032, Peoples R China
[4] Shanghai Inst Liver Dis, Shanghai 200032, Peoples R China
[5] Fudan Univ, Zhongshan Hosp, Dept Respirat, Shanghai 200032, Peoples R China
来源：
CURRENT GENE THERAPY | 2017年 / 17卷 / 06期
关键词：
Epigenetic regulation; Regulatory T cells; Kidney; Transplantation; Treg cells; DNA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FOXP3; EXPRESSION; DEMETHYLATED REGION; MESSENGER-RNA; PLASTICITY; TOLERANCE; METHYLATION; SEVERITY; EFFECTOR; PROTECT;
D O I：
10.2174/1566523218666180214093813
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Regulatory T (Treg) cells are a kind of immunosuppression cells, which have been used to treat autoimmune diseases and induce allograft tolerance in clinical trials. While Treg cells based therapy is a promising treatment for kidney diseases and an emerging concept for tolerance induction in renal transplantation, a better understanding of the functions and biology of Treg cells is needed to be able to optimally exploit them. Epigenetics regulation, which refers to potentially heritable alterations in gene expression without underlying changes of the nucleotide sequence, plays an important role in Treg cells induction and maintenance. The expression of Foxp3, the key factor of Treg cells, is regulated by DNA methylation, histone modification and post-transcriptionally modification. Herein, we review the current understanding of Treg cells in kidney diseases and transplantation, and discuss the epigenetic regulation of Treg cells.
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收藏
页码：461 / 468
页数：8
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