Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study

被引：120

作者：

Zhu, Linling ^{[1
,2
]}

Zhang, Yu ^{[1
,2
]}

Liu, Yifeng ^{[1
,2
]}

Zhang, Runjv ^{[1
,2
]}

Wu, Yiqing ^{[1
,2
]}

Huang, Yun ^{[1
,2
]}

Liu, Feng ^{[1
]}

Li, Meigen ^{[1
]}

Sun, Saijun ^{[1
]}

Xing, Lanfeng ^{[1
]}

Zhu, Yimin ^{[1
,2
]}

Chen, Yiyi ^{[1
]}

Xu, Li ^{[1
]}

Zhou, Liangbi ^{[1
]}

Huang, Hefeng ^{[1
,2
]}

Zhang, Dan ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Womens Hosp, Dept Reprod Endocrinol, Hangzhou 310006, Zhejiang, Peoples R China

[2] Zhejiang Univ, Key Lab Reprod Genet, Minist Educ, Hangzhou 310006, Zhejiang, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM INJECTION; SINGLETON PREGNANCIES; PERINATAL OUTCOMES; INCREASED RISK; IVF; COMPLICATIONS; METAANALYSIS; DEFECTS; ICSI;

D O I：

10.1038/srep35141

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study was carried out to explore associations between assisted reproductive technology (ART) and maternal and neonatal outcomes compared with similar outcomes following spontaneously conceived births. We conducted a retrospective cohort study of pregnancies conceived by ART (N = 2641) during 2006-2014 compared to naturally conceived pregnancies (N = 5282) after matching for maternal age and birth year. Pregnancy complications, perinatal complications and neonatal outcomes of enrolled subjects were investigated and analysed by multivariate logistic regression. We found that pregnancies conceived by in vitro fertilization (IVF) were associated with a significantly increased incidence of gestational diabetes mellitus, gestational hypertension, preeclampsia, intrahepatic cholestasis of pregnancy, placenta previa, placental abruption, preterm premature rupture of membranes, placental adherence, postpartum haemorrhage, polyhydramnios, preterm labour, low birth weight, and small-for-date infant compared with spontaneously conceived births. Pregnancies conceived by intracytoplasmic sperm injection (ICSI) showed similar elevated complications, except some of the difference narrowed or disappeared. Singleton pregnancies or nulliparous pregnancies following ART still exhibited increased maternal and neonatal complications. Therefore, we conclude that pregnancies conceived following ART are at increased risks of antenatal complications, perinatal complications and poor neonatal outcomes, which may result from not only a higher incidence of multiple pregnancy, but also the manipulation involved in ART processes.

引用

页数：11

共 37 条

[1] Pregnancy Outcomes After Assisted Reproductive Technology [J].