Synthesis and biological evaluation of 1,3,4-oxadiazole-linked bisindole derivatives as anticancer agents

被引：54

作者：

Hatti, Islavathu ^{[1
]}

Sreenivasulu, Reddymasu ^{[1
]}

Jadav, Surender Singh ^{[2
]}

Ahsan, Mohamed Jawed ^{[3
]}

Raju, Rudraraju Ramesh ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India

[2] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

[3] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302023, Rajasthan, India

来源：

MONATSHEFTE FUR CHEMIE | 2015年 / 146卷 / 10期

关键词：

Nortopsentins A-C; Hamacanthin B; Zibotentan (ZD4054); Bisindoles; 1,3,4-Oxadiazoles; Cytotoxicity; MARINE ALKALOID NORTOPSENTIN; ANTIMICROBIAL ACTIVITY; ANALOGS; SPONGE; ANTITUMOR; INDOLE-3-CARBINOL; ANTIFUNGAL; TOPSENTIN;

D O I：

10.1007/s00706-015-1448-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of ten 1,3,4-oxadiazole-linked bisindole derivatives have been synthesized. All compounds were evaluated for anticancer activity against four human cancer cell lines (MCF-7, KB, Colo-205, and A-549). Most of these new compounds exhibited significant anticancer activity as compared to etoposide. Compounds' GI(50) values range from < 0.1 to 3.9 mu M, while the positive control etoposide has a GI(50) in the range of 0.13-3.08 mu M in the cell lines employed. Among them, four compounds showed a higher activity than etoposide.

引用

页码：1699 / 1705

页数：7

共 50 条

[31] 1,3,4-Oxadiazole Derivatives as Potential Biological Agents
Sun, Juan
Makawana, Jigar A.
Zhu, Hai-Liang
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2013, 13 (12) : 1725 - 1743
[32] Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents
Cevik, Ulviye Acar
Osmaniye, Derya
Levent, Serkan
Saglik, Begum Nurpelin
Cavusoglu, Betul Kaya
Karaduma, Abdullah Burak
Ozkay, Yusuf
Kaplancikli, Zafer Asim
ACTA PHARMACEUTICA, 2020, 70 (04) : 499 - 513
[33] Synthesis, Biological Evaluation and Docking Studies of 1,3,4-oxadiazole Fused Benzothiazole Derivatives for Anticancer Drugs
Subramanyam, Madala
Sreenivasulu, Reddymasu
Gundla, Rambabu
Rao, Mandava V. B.
Rao, Koya Prabhakara
LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (12) : 1299 - 1307
[34] Synthesis, Antioxidant, and Anticancer Studies of New 1,3,4-Oxadiazole Derivatives Linked to Benzoquinoline
Fadda, Ahmed A.
El-Sawy, Eslam R.
Zidan, T. A.
Abdel-Rahman, Adel A. -H.
El-Sayed, Wael A.
Emam, Dalia R.
CHEMISTRYSELECT, 2024, 9 (28):
[35] Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Derivatives as Acetylcholinesterase Inhibitors
Shun Yang
Jing-Pei Zou
Xiang-Rong Li
Rui Li
Jing-Jing Qian
Wen-Long Wu
Jia-Bin Su
Ke-Qi Chen
Tian Qin
Shan-Ming Liu
Wei-Wei Liu
Da-Hua Shi
Russian Journal of Organic Chemistry, 2022, 58 : 1520 - 1526
[36] Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Derivatives as Acetylcholinesterase Inhibitors
Yang, Shun
Zou, Jing-Pei
Li, Xiang-Rong
Li, Rui
Qian, Jing-Jing
Wu, Wen-Long
Su, Jia-Bin
Chen, Ke-Qi
Qin, Tian
Liu, Shan-Ming
Liu, Wei-Wei
Shi, Da-Hua
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (10) : 1520 - 1526
[37] Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives
Polkam, N.
Malthum, S.
Anireddy, J. S.
Brahma, U.
Vegi, G. M. Naidu
RUSSIAN CHEMICAL BULLETIN, 2021, 70 (03) : 580 - 584
[38] Design, synthesis, modelling studies and biological evaluation of 1,3,4-oxadiazole derivatives as potent anticancer agents targeting thymidine phosphorylase enzyme
Bajaj, Shalini
Kumar, Maushmi S.
Tinwala, Hussain
Mayur, Y. C.
BIOORGANIC CHEMISTRY, 2021, 111
[39] Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives
N. Polkam
S. Malthum
J. S. Anireddy
U. Brahma
G. M. Naidu Vegi
Russian Chemical Bulletin, 2021, 70 : 580 - 584
[40] Design, Synthesis, and Anticancer Evaluation of Novel Benzopyran 1,3,4-oxadiazole Derivatives
Kumar, Piyush
Rahman, Md Azizur
Wal, Pranay
Rawat, Pinki
Singh, Kuldeep
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 30 (03) : 395 - 402

← 1 2 3 4 5 →