Synthesis and biological evaluation of 1,3,4-oxadiazole-linked bisindole derivatives as anticancer agents

被引：54

作者：

Hatti, Islavathu ^{[1
]}

Sreenivasulu, Reddymasu ^{[1
]}

Jadav, Surender Singh ^{[2
]}

Ahsan, Mohamed Jawed ^{[3
]}

Raju, Rudraraju Ramesh ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India

[2] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

[3] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302023, Rajasthan, India

来源：

MONATSHEFTE FUR CHEMIE | 2015年 / 146卷 / 10期

关键词：

Nortopsentins A-C; Hamacanthin B; Zibotentan (ZD4054); Bisindoles; 1,3,4-Oxadiazoles; Cytotoxicity; MARINE ALKALOID NORTOPSENTIN; ANTIMICROBIAL ACTIVITY; ANALOGS; SPONGE; ANTITUMOR; INDOLE-3-CARBINOL; ANTIFUNGAL; TOPSENTIN;

D O I：

10.1007/s00706-015-1448-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of ten 1,3,4-oxadiazole-linked bisindole derivatives have been synthesized. All compounds were evaluated for anticancer activity against four human cancer cell lines (MCF-7, KB, Colo-205, and A-549). Most of these new compounds exhibited significant anticancer activity as compared to etoposide. Compounds' GI(50) values range from < 0.1 to 3.9 mu M, while the positive control etoposide has a GI(50) in the range of 0.13-3.08 mu M in the cell lines employed. Among them, four compounds showed a higher activity than etoposide.

引用

页码：1699 / 1705

页数：7

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