Synthesis and biological evaluation of 1,3,4-oxadiazole-linked bisindole derivatives as anticancer agents

被引：54
|
作者：
Hatti, Islavathu [1 ]
Sreenivasulu, Reddymasu [1 ]
Jadav, Surender Singh [2 ]
Ahsan, Mohamed Jawed [3 ]
Raju, Rudraraju Ramesh [1 ]
机构：
[1] Acharya Nagarjuna Univ, Dept Chem, Nagarjuna Nagar 522510, Andhra Pradesh, India
[2] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India
[3] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302023, Rajasthan, India
来源：
MONATSHEFTE FUR CHEMIE | 2015年 / 146卷 / 10期
关键词：
Nortopsentins A-C; Hamacanthin B; Zibotentan (ZD4054); Bisindoles; 1,3,4-Oxadiazoles; Cytotoxicity; MARINE ALKALOID NORTOPSENTIN; ANTIMICROBIAL ACTIVITY; ANALOGS; SPONGE; ANTITUMOR; INDOLE-3-CARBINOL; ANTIFUNGAL; TOPSENTIN;
D O I：
10.1007/s00706-015-1448-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of ten 1,3,4-oxadiazole-linked bisindole derivatives have been synthesized. All compounds were evaluated for anticancer activity against four human cancer cell lines (MCF-7, KB, Colo-205, and A-549). Most of these new compounds exhibited significant anticancer activity as compared to etoposide. Compounds' GI(50) values range from < 0.1 to 3.9 mu M, while the positive control etoposide has a GI(50) in the range of 0.13-3.08 mu M in the cell lines employed. Among them, four compounds showed a higher activity than etoposide.
引用
收藏
页码：1699 / 1705
页数：7
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