The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components

被引:5
作者
Ren, Hu [1 ,2 ]
Shi, Su-Sheng [2 ,3 ]
Wang, Nian-Chang [1 ,2 ]
Wang, Xing [4 ]
Chen, Ying-Tai [1 ,2 ]
Zhao, Dong-Bing [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Natl Clin Res Ctr Canc, Dept Pancreat & Gastr Surg, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China
[2] Peking Union Med Coll, Beijing 100021, Peoples R China
[3] Chinese Acad Med Sci, Natl Clin Res Ctr Canc, Dept Pathol, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China
[4] Zhejiang Canc Hosp, Dept Head & Neck Surg, Hangzhou 310000, Zhejiang, Peoples R China
基金
国家重点研发计划;
关键词
LYMPH-NODE METASTASIS; GRADE; 3; CELL-CARCINOMA; DIFFERENTIATION; STOMACH; CANCER; HETEROGENEITY; PROGNOSIS;
D O I
10.1155/2019/3671268
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice. Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent. Methods. We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component. We adopted 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, and 90% as the cut-off proportions of the NE component, respectively, and analyzed the patients' overall survival according to the proportion of the NE component. Results. The 1-, 3-, and 5-year actual survival rates of the patients with a NE component were 90.1%, 72.3%, and 67.2%, respectively, and for those without a NE component 94.2%, 79.3%, and 75.7%, respectively. The multivariate analysis showed that the patients with NE components >70% (HR: 2.156; 95% CI: 1.011, 4.597; p=0.047) and >90% (HR: 2.476; 95% CI: 1.088, 5.634; p=0.031) had significantly worse survival than those without a NE component. Only the diameter of tumors (>4.64 cm) (HR: 2.585; 95% CI: 1.112, 6.006; p=0.027) and pN3 (HR: 2.953; 95% CI: 1.051, 8.293; p=0.040) were independently associated with worse overall survival for gastric adenocarcinoma patients with a NE component (all p<0.05). Conclusion. Gastric adenocarcinoma patients with a NE component >70% and >90% have significantly worse survival than those without a NE component. Only the diameter of tumors and the number of metastatic lymph nodes are independent prognostic factors for gastric adenocarcinoma patients with a NE component.
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页数:12
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