Candesartan Cilexetil Determination by Electrode Modified with Hybrid Film of Ionic Liquid-Graphene Nanosheets-Silicon Carbide Nanoparticle Using Continuous Coulometric FFT Cyclic Voltammetry

In this work, a new electrochemical method is introduced for the determination of Candesartan cilexetil using a new sensor and Continuous Coulometric Fast Fourier transformation cyclic voltammetry (CCFFTCV). The new sensor was designed based on silicon carbide nanoparticles and graphene nanosheets hybrid mixed with ionic liquid (1-Butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) on a glassy carbon electrode. The sensor response calculated in form of coulomb by integrating the charge changes under the peak current in a selected potential range. The experimental conditions, for the electrochemical measurement were optimized. The linear concentrations range of Candesartan cilexetil was from 0.5 to 120x10(-8) M with a detection limit of 5.2x10(-9) M. Moreover, the proposed sensor exhibits good accuracy, the response time less than 6s, high sensitivity with repeatability (R.S.D value of 3.5%) and long term stability, 55 days with a decrease of 2.3% in the response.