A unique CD4+ large granular lymphocytosis occurring in patients treated with tumor necrosis factor a inhibitors: report of 2 cases

被引：8

作者：

Covach, Adam ^{[1
]}

Leith, Catherine P. ^{[1
]}

Rajguru, Saurabh A. ^{[2
]}

Yang, David T. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI USA

[2] Univ Wisconsin, Dept Med, Madison, WI USA

来源：

HUMAN PATHOLOGY | 2015年 / 46卷 / 08期

关键词：

Large granular lymphocytosis; LGL; T cell; CD4; Adalimumab; Tumor necrosis factor alpha;

D O I：

10.1016/j.humpath.2015.04.015

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report 2 cases of CD4+ large granular lymphocyte (LGL) lymphocytosis occurring in patients being treated with a monoclonal antibody against tumor necrosis factor a for underlying autoimmune disorders. CD4(+) LGL lymphocytosis is a rare subset of LGL disease that has previously only been described in patients without underlying autoimmune disorders, and most demonstrate uniform coexpression of CD56 on the atypical T cells. The clinical features, with both cases occurring in patients with autoimmune disease, and immunophenotypic features, with both cases showing dim CD8 coexpression without CD56 in the CD4(+) LGLs, suggest that the reported cases are distinct from those previously described and may represent a novel T-cell LGL lymphocytosis emerging from iatrogenic immune modulation of patients with underlying autoimmune disorders. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：1237 / 1241

页数：5

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