Sesquiterpene coumarins from seeds of Ferula sinkiangensis

被引：46

作者：

Li, Guangzhi ^{[1
]}

Li, Xiaojin ^{[2
]}

Cao, Li ^{[1
]}

Zhang, Lijing ^{[1
]}

Shen, Liangang ^{[1
]}

Zhu, Jun ^{[2
]}

Wang, Junchi ^{[1
]}

Si, Jianyong ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Xinjiang Inst Chinese Mat Med & Eth Mat Med, Urumqi 830002, Peoples R China

来源：

FITOTERAPIA | 2015年 / 103卷

基金：

中国国家自然科学基金;

关键词：

Ferula sinkiangensis; Sesquiterpene coumarin; Sesquiterpene; Cytotoxic activities; ROOTS;

D O I：

10.1016/j.fitote.2015.03.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferule sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of the isolated compounds were tested against the AGS, HeLa, and K562 human cancer cell lines and showed cytotoxic activities with 50% inhibitory concentration values between 12.7 and 226.6 mu M. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：222 / 226

页数：5

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