Polycarboxylic fullerene derivatives as protein tyrosine phosphatase inhibitors

被引：12

作者：

Kobzar, Oleksandr L. ^{[1
]}

Trush, Viacheslav V. ^{[1
]}

Tanchuk, Vsevolod Yu. ^{[1
]}

Voronov, Iliya I. ^{[2
]}

Peregudov, Alexander S. ^{[3
]}

Troshin, Pavel A. ^{[2
]}

Vovk, Andriy I. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine

[2] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia

[3] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Chernogolovka 119991, Moscow Region, Russia

来源：

MENDELEEV COMMUNICATIONS | 2015年 / 25卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

CD45; C60CL6; CELLS; PTP1B;

D O I：

10.1016/j.mencom.2015.05.013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The study of the inhibition of human protein tyrosine phosphatases by water-soluble [60]fullerene derivatives bearing five organic addends loaded with carboxylic groups demonstrated that a fullerene core is responsible for interactions with the enzymes while organic addends play a minor role modifying the selectivity of the inhibition.

引用

页码：199 / 201

页数：3

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