In silico biological activity of steroids from the marine sponge Axinella carteri

被引：6
作者：
Anuradha, V. [1 ]
Byju, K. [1 ]
Emilda, Rosmine [1 ]
Anu, Gopinath [2 ]
Nair, S. M. [1 ]
Chandramohanakumar, N. [1 ]
Peter, K. J. Prashob [1 ]
Kumar, T. R. Gireesh [1 ]
Vasundhara, G. [1 ]
机构：
[1] Cochin Univ Sci & Technol, Inter Univ Ctr Dev Marine Biotechnol, Cochin 682016, Kerala, India
[2] St Teresas Coll, Dept Chem, Cochin, Kerala, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 03期
关键词：
Axinella carteri; Steroids; GC-MS; PASS; NGF agonist; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTORS; ACTIVITY SPECTRA; BLOOD-BRAIN; PREDICTION; NGF; RECEPTORS; MIMETICS; LIGANDS; SETS;
D O I：
10.1007/s00044-012-0119-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The steroidal composition of the marine sponge Axinella carteri, collected from Lakshadweep archipelago in the Arabian Sea was found to be a prolific source for a variety of rare steroids. The GC-MS study afforded us with the occurrence of 8 steroids belonging to four different types of nucleus, including the unique occurrence of an unconventional steroid A-norcholestan-2-one in Axinella carteri. The biological activity was predicted using the soft ware PASS. It was found that majority of the steroids extracted from Axinella carteri exhibited the potential of being agonistic to nerve growth factor (NGF).
引用
收藏
页码：1142 / 1146
页数：5
相关论文
共 36 条
  • [11] RECENT STUDIES IN THE MARINE STEROL FIELD
    DJERASSI, C
    [J]. PURE AND APPLIED CHEMISTRY, 1981, 53 (04) : 873 - 890
  • [12] BLOOD-BRAIN-BARRIER PENETRATION AND INVIVO ACTIVITY OF AN NGF CONJUGATE
    FRIDEN, PM
    WALUS, LR
    WATSON, P
    DOCTROW, SR
    KOZARICH, JW
    BACKMAN, C
    BERGMAN, H
    HOFFER, B
    BLOOM, F
    GRANHOLM, AC
    [J]. SCIENCE, 1993, 259 (5093) : 373 - 377
  • [13] Computer-aided prediction for medicinal chemistry via the Internet
    Geronikaki, A.
    Druzhilovsky, D.
    Zakharov, A.
    Poroikov, V.
    [J]. SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2008, 19 (1-2) : 27 - 38
  • [14] Goad L.J., 1978, Marine natural products, VII, P75, DOI DOI 10.1016/B978-0-12-624002-3.50009-7
  • [15] STEROL BIOSYNTHESIS AND METABOLISM IN MARINE-INVERTEBRATES
    GOAD, LJ
    [J]. PURE AND APPLIED CHEMISTRY, 1981, 53 (04) : 837 - 852
  • [16] Novel low-molecular-weight mimetics of the nerve growth factor
    Gudasheva, T. A.
    Antipova, T. A.
    Seredenin, S. B.
    [J]. DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2010, 434 (01) : 262 - 265
  • [17] Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment
    Hellweg, R.
    Ziegenhorn, A.
    Heuser, I.
    Deuschle, M.
    [J]. PHARMACOPSYCHIATRY, 2008, 41 (02) : 66 - 71
  • [18] Multi-Targeted Natural Products Evaluation Based on Biological Activity Prediction with PASS
    Lagunin, Alexey
    Filimonov, Dmitry
    Poroikov, Vladimir
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2010, 16 (15) : 1703 - 1717
  • [19] Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity
    Li, YS
    Ishibashi, M
    Satake, M
    Chen, XG
    Oshima, Y
    Ohizumi, Y
    [J]. JOURNAL OF NATURAL PRODUCTS, 2003, 66 (05): : 696 - 698
  • [20] Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms
    Longo, Frank M.
    Yang, Tao
    Knowles, Juliet K.
    Xie, Youmei
    Moore, Laura A.
    Massa, Stephen M.
    [J]. CURRENT ALZHEIMER RESEARCH, 2007, 4 (05) : 503 - 506
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