In silico biological activity of steroids from the marine sponge Axinella carteri

被引：6

作者：

Anuradha, V. ^{[1
]}

Byju, K. ^{[1
]}

Emilda, Rosmine ^{[1
]}

Anu, Gopinath ^{[2
]}

Nair, S. M. ^{[1
]}

Chandramohanakumar, N. ^{[1
]}

Peter, K. J. Prashob ^{[1
]}

Kumar, T. R. Gireesh ^{[1
]}

Vasundhara, G. ^{[1
]}

机构：

[1] Cochin Univ Sci & Technol, Inter Univ Ctr Dev Marine Biotechnol, Cochin 682016, Kerala, India

[2] St Teresas Coll, Dept Chem, Cochin, Kerala, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 03期

关键词：

Axinella carteri; Steroids; GC-MS; PASS; NGF agonist; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTORS; ACTIVITY SPECTRA; BLOOD-BRAIN; PREDICTION; NGF; RECEPTORS; MIMETICS; LIGANDS; SETS;

D O I：

10.1007/s00044-012-0119-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The steroidal composition of the marine sponge Axinella carteri, collected from Lakshadweep archipelago in the Arabian Sea was found to be a prolific source for a variety of rare steroids. The GC-MS study afforded us with the occurrence of 8 steroids belonging to four different types of nucleus, including the unique occurrence of an unconventional steroid A-norcholestan-2-one in Axinella carteri. The biological activity was predicted using the soft ware PASS. It was found that majority of the steroids extracted from Axinella carteri exhibited the potential of being agonistic to nerve growth factor (NGF).

引用

页码：1142 / 1146

页数：5

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